Development of diagnostics and treatment of serious heart and vascular diseases using genomic and proteomic approaches
Public support
Provider
Ministry of Education, Youth and Sports
Programme
Health and quality of life
Call for proposals
Zdravý a kvalitní život 2 (SMSM20082B2)
Main participants
—
Contest type
VS - Public tender
Contract ID
1182/2010-31
Alternative language
Project name in Czech
Vývoj diagnostiky a léčby závažných onemocnění srdce a cév pomocí genomických a epigenomických přístupů
Annotation in Czech
Očekávaným cílem projektu je zavedení nových molekulárně genetických, genomických a proteomických přístupů v diagnostice závažných onemocnění srdce a cév.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FA - Cardiovascular diseases including cardio-surgery
CEP - secondary branch
EB - Genetics and molecular biology
CEP - another secondary branch
CE - Biochemistry
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30201 - Cardiac and Cardiovascular systems
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
Analysis of genes associated with FH was performed in 2239 patients - in 267 and 535 of them mutations were detected in APOB and LDLR resp. Statistical analyses of lipid profiles were performed. Two mechanisms of deletion/duplication formation were described - NAHR and NHEJ. The chip for diagnostics FH was introduced, as well as methods for analysis of histone modifications by LC-MS/MS, MALDI-MS.
Solution timeline
Realization period - beginning
Mar 1, 2008
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Feb 25, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-MSM-2B-U/01:1
Data delivery date
Jul 3, 2012
Finance
Total approved costs
27,550 thou. CZK
Public financial support
24,678 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
2,872 thou. CZK