Novel treatment of genetically determined metabolic disease, type 1 diabetes, using an immunotherapeutical approach.
Project goals
The aim of the proposed project is a characterization of genetical profile of patients with type 1 diabetes mellitus (T1D) and induction of specific immune tolerance. Immunotherapeutical approaches could achieve complete cure of T1D or reverse unfavourable development of this serious disease (and prevent cardiovascular and metabolical complications of the patients). Project is focused on creation of laboratory procedure which would lead to clinical application of immunological preparation based on genetically modified tolerogenic T lymphocytes and dendritic cells. This therapeutical approach could be also original medical treatment for wider spectra of autoimmune disease such as multiple sclerosis and rheumatoid arthritis.
Keywords
Type 1 diabetesimmunotherapyautoimmunitygenetical determinationFoxp3
Public support
Provider
Ministry of Education, Youth and Sports
Programme
Health and quality of life
Call for proposals
Zdravý a kvalitní život 2 (SMSM20082B2)
Main participants
—
Contest type
VS - Public tender
Contract ID
1182/2010-31
Alternative language
Project name in Czech
Studium léčebných možností diabetes mellitus 1. typu jako geneticky determinované metabolické choroby s využitím nových imunoterapeutických postupů
Annotation in Czech
Cílem projektu je charakteristika genetického profilu pacientů s diabetes mellitus 1. typu a navození specifické imunitní tolerance vůči diabetogenním antigenům metodami genového inženýrství a imunologie.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FB - Endocrinology, diabetology, metabolism, nutrition
CEP - secondary branch
EC - Immunology
CEP - another secondary branch
EB - Genetics and molecular biology
10603 - Genetics and heredity (medical genetics to be 3)
10604 - Reproductive biology (medical aspects to be 3)
10605 - Developmental biology
10608 - Biochemistry and molecular biology
10609 - Biochemical research methods
30101 - Human genetics
30102 - Immunology
30202 - Endocrinology and metabolism (including diabetes, hormones)
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
In the course of the research plan solving the annotated methodologies have been thoroughly fulfilled, and that related to the scheduled terms as well as expert scope of activities. Submitted final solution is the example of successful cooperation of universities and Academy of Sciences with the practice. A number of significant results has been achieved.
Solution timeline
Realization period - beginning
May 1, 2008
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Feb 25, 2011
Data delivery to CEP
Confidentiality
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.
Data delivery code
CEP12-MSM-2B-U/01:1
Data delivery date
Jul 3, 2012
Finance
Total approved costs
44,736 thou. CZK
Public financial support
38,751 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
5,985 thou. CZK
Basic information
Recognised costs
44 736 CZK thou.
Public support
38 751 CZK thou.
86%
Provider
Ministry of Education, Youth and Sports
CEP
FB - Endocrinology, diabetology, metabolism, nutrition
Solution period
01. 05. 2008 - 31. 12. 2011