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Impact of neonatal colonization with bifidobacteria on the development of allergic sensitization in gnotobiotic mouse model of Type I allergy

Project goals

The aims of this projects are: 1) To characterize in detail the immunomodulatory properties of B. longum ssp. longum CCDM367 strain in vitro 2) To characterize the impact of neonatal colonization on allergic sensitization to Bet v 1 in gnotobiotic modelof type I. allergy 3) To evaluate the correlation of in vitro obtained data with the effect from in vivo gnotobiotic model 4) To establish cooperation between the laboratories of Czech and Austrian partner 5) Transfer and establishment of methods betweenpartners

Keywords

allergyprobioticsbifidobacteriaallergic sensitization

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

  • Call for proposals

    FP6-2002-Mobility-12

  • Main participants

  • Contest type

    RP - Co-financing of EC programme

  • Contract ID

    MSMT-2956/2012-36

Alternative language

  • Project name in Czech

    Vliv neonatální kolonizace bifidobakteriemi na vývoj alergické sensibilizace u myšího gnotobiotického modelu alergie I. typu

  • Annotation in Czech

    Cíle projektu jsou: 1) Detailně charakterizovat imunomodulační vlastnosti kmene Bifidobacterium longum ssp. longum in vitro 2) Zjistit vliv neonatální kolonizace na sensibilizaci k hlavnímu březovému alergenu Bet v 1 v gnotobiotickém modelu alergie I. typu 3) Srovnat výsledky z in vitro pokusů s efektem pozorovaným v in vivo gnotobiotickém modelu 4) Založit úzkou spolupráci mezi laboratořemi českého a rakouského partnera 5) Sdílení a zavedení nových metod v laboratořích obou partnerů

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    EC - Immunology

  • CEP - secondary branch

    EE - Microbiology, virology

  • CEP - another secondary branch

    ED - Physiology

  • 10606 - Microbiology
    10607 - Virology
    30102 - Immunology
    30105 - Physiology (including cytology)

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    This project is being realized in the framework of the MOBILITY Activity that aims primarily on establishing and strenghtening ties with foreign research institutions. The control of particular outputs is not implemented by the evalution committee, but the correctness of allocated finances and the adequacy of their use are checked.

Solution timeline

  • Realization period - beginning

    Jan 1, 2012

  • Realization period - end

    Dec 31, 2013

  • Project status

    U - Finished project

  • Latest support payment

    Feb 18, 2013

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP14-MSM-7A-U/01:1

  • Data delivery date

    Jun 30, 2014

Finance

  • Total approved costs

    122 thou. CZK

  • Public financial support

    122 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK

Basic information

Recognised costs

122 CZK thou.

Public support

122 CZK thou.

100%


Provider

Ministry of Education, Youth and Sports

CEP

EC - Immunology

Solution period

01. 01. 2012 - 31. 12. 2013