Desing of a vaccine to immunize neonates against GBS infections through a durable maternal immune response
Public support
Provider
Ministry of Education, Youth and Sports
Programme
—
Call for proposals
FP7-HEALTH-2007-A
Main participants
—
Contest type
RP - Co-financing of EC programme
Contract ID
3094/2010-32
Alternative language
Project name in Czech
Desing of a vaccine to immunize neonates against GBS infections through a durable maternal immune response
Annotation in Czech
Direct vaccination cannot prevent diseases that affect neonates in the first days of live. Group B Streptococcus (GBS) is the major cause of neonatal septicemia nd meningitis affecting up to one in every thousand live births. Over 80% of cases occur in the first 7 days after birth and the remaining 20% of disease occurs between 8-90 days after birth. Studies carried out in the USA indicate that high titres of maternal antibody to GBS capsular polysaccharides (CPS) correlate with reduced risk of diseasesin neonates suggesting that maternal immunization may be an effective strategy for delivery of a protective immune response to the child in this early period. The overall objective of this proposal is to design immunization strategies capable of inducing strong durable and placentally transferable protective immune responses agains GBS in women in order to fill this gap in early infancy when direct immunization is not possible.Starting with the genome sequenceof 8 strains of GBS, Novartis scientist
Scientific branches
R&D category
AP - Applied research
CEP classification - main branch
FN - Epidemiology, infection diseases and clinical immunology
CEP - secondary branch
EE - Microbiology, virology
CEP - another secondary branch
EC - Immunology
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10606 - Microbiology<br>10607 - Virology<br>30102 - Immunology<br>30302 - Epidemiology<br>30303 - Infectious Diseases
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider
Solution timeline
Realization period - beginning
Jan 1, 2008
Realization period - end
Dec 31, 2010
Project status
U - Finished project
Latest support payment
Apr 27, 2010
Data delivery to CEP
Confidentiality
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.
Data delivery code
CEP11-MSM-7E-U/01:1
Data delivery date
Jun 30, 2011
Finance
Total approved costs
2,508 thou. CZK
Public financial support
2,508 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK