IPODD?IBD: proteases offer new targets for drug discovery

Project name in Czech
IPODD?IBD: proteases offer new targets for drug discovery
Annotation in Czech
The inflammatory bowel diseases (IBD) which comprise Crohn?s disease and ulcerative colitis are chronic relapsing and remitting inflammatory disorders of the gastrointestinal tract. The frequency of these conditions has increased in recent decades, particularly in countries making the transition from developing to developed nation status. In western Europe, IBD now affects between 1/1000 and 5/1000 of the population, and the prevalence of the conditions in new EU accession countries appears to be growing as they develop. Few conditions in all of clinical medicine are linked with as much morbidity and potential mortality as IBD. Current treatment is based upon steroid therapy or neutralizing the effect of pro-inflammatory cytokines, especially TNFalpha.Despite their efficacy, many patients eventually require surgery for refractory disease or complications (stricture, perforation, abscess). In response to the call we have assembled a multidisciplinary team of international experts to delineate the roleof intestinal proteases and their inhibitors in the pathophysiology of IBD. A particularly innovative aspect of our approach is the examination of both bacterial and host derived proteases and interactions between the two. The ultimate aim is develop novel therapeutics and increased understanding of the disease both of which will impact within the wider EU community and globally.

R&D category
ZV - Basic research
CEP classification - main branch
EC - Immunology
CEP - secondary branch
EE - Microbiology, virology
CEP - another secondary branch
EB - Genetics and molecular biology
OECD FORD - equivalent branches (according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3) 10604 - Reproductive biology (medical aspects to be 3) 10605 - Developmental biology 10606 - Microbiology 10607 - Virology 10608 - Biochemistry and molecular biology 10609 - Biochemical research methods 30101 - Human genetics 30102 - Immunology

Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.

Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-MSM-7E-U/01:1
Data delivery date
Jul 12, 2012

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