Fighting Aneurysmal Disease

Provider

Ministry of Education, Youth and Sports

Programme

—

Call for proposals

FP7-HEALTH-2007-A

Main participants

—

Contest type

RP - Co-financing of EC programme

Contract ID

1089/2011-321

Project name in Czech

Fighting Aneurysmal Disease

Annotation in Czech

Fighting Aneurysmal Disease (FAD) is a public health in EU, because of the ageing population in the absence of intervention, aneurysms evolve towards rupture and death.The objectives of the project are to accelerate the aquisition of knowledge, and to develop new diagnostic and therapeutic tools for FAD in humans.The project innovates by integrating two different localizations differing in their initial etiologies but similar in their evolution FAD will be built by pooling existing and new clinical andbiological databases in EU.Tissue and cell banks will be constituted.The deliverables will be the standardization of clinical and biological procedures and the recording of all the materialavailable in the consortium.These databases will provide a basisfor genetic studies.Pathophysiology of aneurysms will be explored through human tissue and experimental models in transgenic animals, focusing on the role of proteases and their source within diseased tissues. Human databases, genetic and pathophysiological concepts will provide basis for the development of new diagnostic tools: genetic screening, identification of new surogate markers, validation of candidate markers and discovery of new ones by proteomic aproaches, and functional imaging, visualizingin situ various biological activities.These new molecules/cells of interest will be targeted in preclinical therapeutic approaches, using animal models, and by developing clinical trials. The objective of FAD wiáll be achieved through the organization ofa consortium, grouping 15 partners, integrating numerous medical and scientific disciplines.The consortium includes academic partners from 10 different EU countries, a Turkish research team, and 3 industrial partners.The acquired scientific and technological knowledges will be disseminated through training sessions, participation in European meetings, communication toward industry, and direct relationships with patient associations.

R&D category

AP - Applied research

CEP classification - main branch

FJ - Surgery including transplantology

CEP - secondary branch

FA - Cardiovascular diseases including cardio-surgery

CEP - another secondary branch

EB - Genetics and molecular biology

OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30201 - Cardiac and Cardiovascular systems<br>30212 - Surgery<br>30213 - Transplantation

Provider evaluation

U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

Project results evaluation

Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.

Realization period - beginning

Nov 1, 2009

Realization period - end

Oct 31, 2012

Project status

U - Finished project

Latest support payment

Apr 2, 2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP13-MSM-7E-U/01:1

Data delivery date

Jun 28, 2013

Total approved costs

2,936 thou. CZK

Public financial support

2,936 thou. CZK

Other public sources

0 thou. CZK

Non public and foreign sources

0 thou. CZK