NAnosystems for the early DIagnosis of NEurodegenerative Diseases
Public support
Provider
Ministry of Education, Youth and Sports
Programme
—
Call for proposals
FP7-NMP-2009-LARGE-3
Main participants
—
Contest type
RP - Co-financing of EC programme
Contract ID
MSMT-1840/2013-310
Alternative language
Project name in Czech
NAnosystems for the early DIagnosis of NEurodegenerative Diseases
Annotation in Czech
Medical diagnosis is currently undergoing a major revolution due to the fast discovery of molecular biomarkers, and the development of multimodal ?metabiomarker? signatures. Progress, however, is hindered by the low abundance of many biomarkers of interest in body fluids, in absolute concentration and with regard to other biomolecules. The aim of the NADINE project is to apply progresses in biotechnology, nanoparticle synthesis, and nano-instrumentation to the development of fully integrated lab-on chipinstruments able to perform elaborate multimodal biomarker analysis on a routine basis and at the ultrasensitive level required to allow minimally invasive tests. In particular, we aim at overcoming a major bottleneck on the path to this objective, which was identified in a previous project in the ?HEALTH? priority: no satisfactory solution currently exists to bridge the several orders of magnitude difference between the nanoscale volumes at which ultrasensitive new generation sensors operate, and theoften millilitre volumes of samples in which the molecules of interest must be found. For this, we shall combine innovations in pre-concentration, micro and nanofluidics, self- assembly, micro-nanofabrication, and nanodetection. The project will developa generic, multipurpose, platform of compatible enabling technologies, and integrate them into an automated device. In order to maximize impact and societal benefit, the project will be validated on the early detection of biomarkers for neurodegenerativediseases, notably Alzheimer, and subtyping of these diseases for improved treatment strategies. The project involves a multidisciplinary consortium of technology developers, three leading biomedical groups in clinical neuroscience for definition of specifications and end-user pre-clinical validation, three research-oriented SMEs in biotechnology, nanosensing and microfluidics and a pharmaceutical company.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
CE - Biochemistry
CEP - secondary branch
EI - Biotechnology and bionics
CEP - another secondary branch
FP - Other medical fields
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>20801 - Environmental biotechnology<br>20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management<br>20803 - Environmental biotechnology related ethics<br>20901 - Industrial biotechnology<br>20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation<br>20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials<br>30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30401 - Health-related biotechnology<br>30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)<br>30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])<br>30404 - Biomaterials (as related to medical implants, devices, sensors)<br>30405 - Medical biotechnology related ethics<br>30501 - Forensic science<br>30502 - Other medical science<br>40401 - Agricultural biotechnology and food biotechnology<br>40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming<br>40403 - Agricultural biotechnology related ethics
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.
Solution timeline
Realization period - beginning
Jan 1, 2012
Realization period - end
Dec 31, 2014
Project status
U - Finished project
Latest support payment
Mar 27, 2014
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP15-MSM-7E-U/01:1
Data delivery date
Jul 2, 2015
Finance
Total approved costs
2,385 thou. CZK
Public financial support
2,385 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK