PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood

Provider

Ministry of Education, Youth and Sports

Programme

—

Call for proposals

7E13036-2013

Main participants

Fakultní nemocnice v Motole

Contest type

RP - Co-financing of EC programme

Contract ID

MSMT-42111/2013

Project name in Czech

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood

Annotation in Czech

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The goal of PanCareLIFE is that survivors of cancer diagnosed before age 25 should enjoy the same quality of life and opportunities as their peers who have not had cancer. Using observational studies and molecular genetic investigations PanCareLIFE will investigate late effects that impact fertility and hearing impairment (ototoxicity), and will assess health-related quality of life. Information from PanCareLIFE’s studies will be incorporated into new guidelines for fertility preservation. As the number of survivors with late effects in any one country is small, large cohorts are required for accurate estimation of risk. PanCareLIFE has assembled a team of prominent investigators from 8 European countries who will contribute in total over 12,000 well-characterised research subjects to identify risk factors, both genetic and non-genetic, linked to decrements in fertility and ototoxicity. Quality-of-life studies will evaluate the impact of fertility and ototoxicity. PanCareLIFE will advance the state-of-the-art in survivorship studies by evaluation of large cohorts with observational and genetic tools that will provide better knowledge of individual risk factors. Survivors can then be stratified into groups benefitting from personalized, evidence-based, care; future patients may expect effective therapies to have less severe side effects, and plans for a seamless transition to long-term follow-up care can be made. These approaches will result in better quality of life for survivors of cancer diagnosed at a young age.

R&D category

AP - Applied research

CEP classification - main branch

FD - Oncology and haematology

CEP - secondary branch

FK - Gynaecology and obstetrics

CEP - another secondary branch

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

30204 - Oncology<br>30205 - Hematology<br>30206 - Otorhinolaryngology<br>30207 - Ophthalmology<br>30208 - Dentistry, oral surgery and medicine<br>30214 - Obstetrics and gynaecology

Provider evaluation

U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

Project results evaluation

Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.

Realization period - beginning

Nov 1, 2013

Realization period - end

Oct 31, 2018

Project status

U - Finished project

Latest support payment

Feb 14, 2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP19-MSM-7E-U/01:1

Data delivery date

Jun 18, 2019

Total approved costs

1,596 thou. CZK

Public financial support

1,596 thou. CZK

Other public sources

0 thou. CZK

Non public and foreign sources

0 thou. CZK