Regulation and manipulation of plant meiosis
Public support
Provider
Ministry of Education, Youth and Sports
Programme
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Call for proposals
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Main participants
Masarykova univerzita / Středoevropský technologický institut
Contest type
OP - EU Operational Programme
Contract ID
CZ.02.1.01/0.0/0.0/15_003/0000479
Alternative language
Project name in Czech
Regulace rostlinné meiózy
Annotation in Czech
Účelem projektu je posílit vědeckou excelenci centra CEITEC skrze výzkumný tým Karla Říhy a splnit jeho základní materiálové, infrastrukturní a personální potřeby tak, aby se tento tým mohl plně věnovat prvotřídnímu výzkumu přispívajícímu k celkovým rozvojovým cílům centra.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
EF - Botany
CEP - secondary branch
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CEP - another secondary branch
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OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10611 - Plant sciences, botany<br>10612 - Mycology
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
The REMAP project had three main scientific goals, which were focused on the study of meiosis in the model plant Arabidopsis thaliana. These included the identification and functional characterization of new genes involved in meiotic progression, the introduction of real-time imaging of plant meiosis and the development of a protocol for the delivery of biologically active compounds to plant meiocytes. All these goals were successfully met. The REMAP project helped to develop and characterize a Ku protein inhibitor. This substance causes telomere shortening and arrests the cell cycle of human cells in the S-phase. Further development of this substance may lead to anti-tumor drugs. This research was the subject of two patent applications. The first patent describes a Ku inhibitor and its effect on tumor cells, and the second describes a method to determine the specificity of the inhibitor in a chemical screen.
Solution timeline
Realization period - beginning
Dec 23, 2016
Realization period - end
Oct 31, 2022
Project status
U - Finished project
Latest support payment
Sep 6, 2020
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP23-MSM-EF-U
Data delivery date
Jul 24, 2023
Finance
Total approved costs
97,817 thou. CZK
Public financial support
97,817 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
4,847 thou. CZK