*Development of cultivation and purification technologies for industrial production of recombinant vaccines.
Public support
Provider
Ministry of Industry and Trade
Programme
TANDEM
Call for proposals
TANDEM 2 (SMPO200500008)
Main participants
—
Contest type
VS - Public tender
Contract ID
FT-TA2/025
Alternative language
Project name in Czech
*Vývoj kultivačních a purifikačních technologií pro průmyslovou produkci rekombinantních vakcín.
Annotation in Czech
*Výzkum možností exprese imunogenních proteinů v mikrobiálních hostitelských průmyslově osvědčených kulturách, vytvoření expresního rekombinantního produkčního kmene a jeho kultivační charakteristika. Optimalizace a automatizace produkce proteinů v průmyslových objemech, izolace a purifikace imunogenních proteinů. Příprava prototypů vakcín pro specifickou imunoprofylaxi domácích a hospodářských zvířat.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
EI - Biotechnology and bionics
CEP - secondary branch
GJ - Diseases and animal vermin, veterinary medicine
CEP - another secondary branch
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OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
20801 - Environmental biotechnology<br>20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management<br>20803 - Environmental biotechnology related ethics<br>20901 - Industrial biotechnology<br>20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation<br>20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials<br>30401 - Health-related biotechnology<br>30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)<br>30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])<br>30404 - Biomaterials (as related to medical implants, devices, sensors)<br>30405 - Medical biotechnology related ethics<br>40301 - Veterinary science<br>40401 - Agricultural biotechnology and food biotechnology<br>40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming<br>40403 - Agricultural biotechnology related ethics
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
Candidate gens were selected and inserted to express E.coli. Industrial cultivation, expression and prurification of this proteins were verified. Prototype of vaccine against Actinobacillus diseasy of pigs recombinant was prepared and tested.
Solution timeline
Realization period - beginning
May 1, 2005
Realization period - end
Dec 31, 2008
Project status
U - Finished project
Latest support payment
Apr 18, 2008
Data delivery to CEP
Confidentiality
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.
Data delivery code
CEP09-MPO-FT-U/02:2
Data delivery date
Apr 14, 2010
Finance
Total approved costs
27,760 thou. CZK
Public financial support
18,986 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
8,775 thou. CZK