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Bioinspired Nanocomposite Structures for bone Tissue Regeneration

Public support

  • Provider

    Czech Science Foundation

  • Programme

    Standard projects

  • Call for proposals

    Standardní projekty 12 (SGA02009GA-ST)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    106-09-1000

Alternative language

  • Project name in Czech

    Bioinspirativní nanokompozitní struktury pro obnovu kostní tkáně

  • Annotation in Czech

    Cílem tohoto grantového projektu je příprava biologicky insipirovaného nanokompozitního materiálu pro obnovu kostní tkáně, který bude imitovat reálnou strukturu kosti a zároveň kombinovat výhody nanovláken, makroporézních gelů a bioaktivního anorganického plniva. Tento materiál bude složen z  matrice, představované jednak relativně rychle degradovatelnými hydrogely na bázi methakrylátu nebo makroporézním hydrogelem na bázi přírodního kolagenu (oba typy matrice budou obohaceny kyselinou hyaluronovou). Materiál bude dále obsahovat kolagenní nebo polylaktidová nanovlákna a anorganické plnivo (přírodní nebo syntetický hydroxyapatit příp. trikalciumfosfát). Kompozity budou mechanicky testovány a bude studován vliv celých kompozitů i jednotlivých jejich složek na adhezi, růst, proliferaci, maturaci, životaschopnost a potenciální imunitní aktivaci osteogenních buněk (in vitro testy).

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    FP - Other medical fields

  • CEP - secondary branch

    EI - Biotechnology and bionics

  • CEP - another secondary branch

    JI - Composite materials

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)<br>20801 - Environmental biotechnology<br>20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management<br>20803 - Environmental biotechnology related ethics<br>20901 - Industrial biotechnology<br>20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation<br>20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials<br>30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30401 - Health-related biotechnology<br>30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)<br>30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])<br>30404 - Biomaterials (as related to medical implants, devices, sensors)<br>30405 - Medical biotechnology related ethics<br>30501 - Forensic science<br>30502 - Other medical science<br>40401 - Agricultural biotechnology and food biotechnology<br>40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming<br>40403 - Agricultural biotechnology related ethics

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    The objectives of the project were fulfilled, with an exception of cell testing in a dynamic cultivation system. The created high-ranking publications are dedicated to many projects, so that the quality and quantity of outputs is lower in relation to thecosts. Some additional prepared publications promise to improve this situation.

Solution timeline

  • Realization period - beginning

    Jan 1, 2009

  • Realization period - end

    Dec 31, 2012

  • Project status

    U - Finished project

  • Latest support payment

    Apr 1, 2012

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP13-GA0-GA-U/02:3

  • Data delivery date

    May 17, 2016

Finance

  • Total approved costs

    6,216 thou. CZK

  • Public financial support

    6,216 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK