Defined low molecular weight chitosan biomaterial as a multivalent carrier for bioactive glycans
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Mikrobiologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-20862S
Alternative language
Project name in Czech
Defined low molecular weight chitosan biomaterial as a multivalent carrier for bioactive glycans
Annotation in Czech
Chitosan is a linear polymer, which is biodegradable, biocompatible, non-toxic and therefore predestined for use in a variety of biological, biomedical applications. However, chitosan is also a very heterogeneous material that is difficult to define. Shorter chitosan chains (COS, 2-25 units) with varying degrees of acetylation are suitable for biological applications. The usual hydrolysis of long chitosan chains by concentrated hydrochloric acid results in a heterogeneous mixture of short COS that is difficult to separate, and the kinetics of this reaction are additionally difficult to control. This project focuses on the tunable recovery of defined low molecular weight chitosan with low polydispersity by two processes: (i) deacetylation of chitin and subsequent hydrolysis of chitosan using organic/inorganic acids in solid-state assembly or (ii) alkali-catalyzed one-step mechanochemical deacetylation and depolymerization of chitin. Defined COS material will be used as multivalent, biocompatible carriers of glycomimetics and carbohydrates to target biomedically important lectins.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10404 - Polymer science
OECD FORD - secondary branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
OECD FORD - another secondary branch
—
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
CD - Macromolecular chemistry<br>EI - Biotechnology and bionics
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Apr 27, 2026
Finance
Total approved costs
7,609 thou. CZK
Public financial support
7,609 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK