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Induction of mitochondria in white fat: a common target for treatments ameliorating obesity and insulin resistance

Public support

  • Provider

    Czech Science Foundation

  • Programme

    Standard projects

  • Call for proposals

    Standardní projekty 11 (SGA02008GA-ST)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    303-08-0664

Alternative language

  • Project name in Czech

    Indukce mitochondrií v bílé tukové tkáni: společný cíl terapeutických postupů v léčbě obezity a inzulinové rezistence

  • Annotation in Czech

    Je zapotřebí zlepšit prevenci a léčbu obezity a metabolického syndromu (MS). Nové strategie mohou být založeny na kombinace příjmu n-3 polynenasycené mastné kyseliny (n-3 PUFA), léčby thiazolidindiony (TZD) a kalorické restrikce (CR). Všechny tyto přístup

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    FB - Endocrinology, diabetology, metabolism, nutrition

  • CEP - secondary branch

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Effects of n-3 fatty acids from sea fish in combination with either calorie restriction or thiazolidinediones, the insulinsensitizing drugs, were studied in mice fed a high-fat diet. In both cases, the results revealed synergistic beneficial effects on obesity and associated metabolic disorders. The results were published in seven journal articles with IF.

Solution timeline

  • Realization period - beginning

    Jan 1, 2008

  • Realization period - end

    Dec 31, 2012

  • Project status

    U - Finished project

  • Latest support payment

    Apr 1, 2012

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP13-GA0-GA-U/02:3

  • Data delivery date

    May 17, 2016

Finance

  • Total approved costs

    6,619 thou. CZK

  • Public financial support

    6,619 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK