Mechanisms of antihypertensive action of high potassium intake in salt hypertension
Project goals
Increased dietary K+ intake belongs to important components of antihypertensive therapy. There are several unresolved questions a) the difference in mechanisms of preventive and therapeutic action of high K+ intake, b) the effect of high K+ intake in salt-sensitive and -resistant animals, c) the effects of high K+ intake in relation to the age and/or hypertension stage. Using rats with salt or genetic hypertension we would like to elucidate 1) mechanisms of age-dependent antihypertensive action of highK+ intake, namely the role of sympathetic nervous system and NO, 2) therapeutic effects of high K+ intake in young and adult rats with established hypertension, 3) role of enhanced superoxide production at normal or high K+ intake, 4) antihypertensive effects of high K+ intake during chronic blockade of NO synthase or NADPH oxidase, and 5) influence of K+ depletion on the activity of various K+ channels involved in the control of smooth muscle tone in resistance vessels. Our results might contribute tothe rationalization of antihypertensive therapy in particular forms of hypertension.
Keywords
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
Standardní projekty 12 (SGA02009GA-ST)
Main participants
—
Contest type
VS - Public tender
Contract ID
305/09/0336
Alternative language
Project name in Czech
Mechanismy antihypertenzního působení zvýšeného příjmu draslíku u solné hypertenze
Annotation in Czech
Cílem tohoto projektu je objasnit mechanismy věkově závislého preventivního a terapeutického účinku vysokého příjmu K+ u různých forem hypertenze, se zřetelem k úloze sympatiku, oxidu dusnatého, nadprodukce superoxidů a vybraných draslíkových kanálů účastnících se kontroly tonu odporových cév.
Scientific branches
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
The project gone according to plan both in terms of expertise and in terms of disbursement of funds.
Solution timeline
Realization period - beginning
Jan 1, 2009
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Apr 16, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-GA0-GA-U/02:2
Data delivery date
May 2, 2016
Finance
Total approved costs
3,060 thou. CZK
Public financial support
3,060 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Basic information
Recognised costs
3 060 CZK thou.
Public support
3 060 CZK thou.
0%
Provider
Czech Science Foundation
CEP
FA - Cardiovascular diseases including cardio-surgery
Solution period
01. 01. 2009 - 31. 12. 2011