The role of PAR-2 in neurodegenerative diseases
Project goals
Proteinase-activated receptors are essentially ubiquitous receptors activated by certain serine proteinases. This is a family of G-protein coupled receptors activated by subsequent cleavage at the specific site of the NH2 terminal and presentation of the new terminal, which behaves as "a tethered ligand". Neurodegenerative diseases are very serious confirmed diseases which incidence is sharply increasing in relation to the aging of the population. Based on the literature and according to our previous finding we assume that serum proteinases play an important role in the pathophysiology of degenerative diseases of CNS via activation of PAR´s. We further assume that these processes are closely linked to the blood-brain barrier damage by endogenous or exogenous factors. To observe the role of PAR in degenerative processes of CNS the PAR-2 changes of expressions will be followed and compared to other neurodegenerative markers in animal models. The obtained results will be compared to the observation of the changes of expression of PAR´s in the model of human samples of neurodegenerative disorders. The human samples will be obtained from the collection of neuropathological material of autoptic CNS tissues affected by different neurodegenerative diseases.
Keywords
Public support
Provider
Czech Science Foundation
Programme
Post-graduate (doctorate) grants
Call for proposals
Postdoktorandské granty 9 (SGA02009GA1PD)
Main participants
—
Contest type
VS - Public tender
Contract ID
309/09/P204
Alternative language
Project name in Czech
Úloha PAR-2 v neurodegenerativních onemocněních
Annotation in Czech
Cílem předkládaného projektu je zjistit zda a jakým způsobem se proteinázy trypsin a trombin a jejich agonistické molekuly podílí na patogenezi neurodegenerativních onemocnění prostřednictvím aktivace PAR´s.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FH - Neurology, neuro-surgery, nuero-sciences
CEP - secondary branch
EB - Genetics and molecular biology
CEP - another secondary branch
EA - Morphology and cytology
10601 - Cell biology
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
10603 - Genetics and heredity (medical genetics to be 3)
10604 - Reproductive biology (medical aspects to be 3)
10605 - Developmental biology
10608 - Biochemistry and molecular biology
10609 - Biochemical research methods
30101 - Human genetics
30103 - Neurosciences (including psychophysiology)
30210 - Clinical neurology
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
The project was excellent, both in terms of expertise and in terms of disbursement of funds.
Solution timeline
Realization period - beginning
Jan 1, 2009
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Apr 16, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-GA0-GP-U/03:3
Data delivery date
May 2, 2016
Finance
Total approved costs
1,797 thou. CZK
Public financial support
1,797 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Basic information
Recognised costs
1 797 CZK thou.
Public support
1 797 CZK thou.
100%
Provider
Czech Science Foundation
CEP
FH - Neurology, neuro-surgery, nuero-sciences
Solution period
01. 01. 2009 - 31. 12. 2011