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LD12071

Control of plant viruses by RNA based vaccines

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    COST CZ

  • Call for proposals

    COST CZ 2 (SMSM2012LD2)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    MSMT-7027/2012-36

Alternative language

  • Project name in Czech

    Kontrola rostlinných virů pomocí RNA-vakcín

  • Annotation in Czech

    Cílem projektu je navržení genomických segmentů odvozených od ekonomicky významných potyvirů (PSbMV, ZYMV) vhodných pro přípravu dsRNA molekul a jejich syntéza. Získání nových poznatků o úloze siRNA v patogenezi rostlinných virů, o stabilitě a durabilitěsiRNA aktivovaného umlčování genu vyvolaného aplikací uměle syntetizovaných dsRNA molekul.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    EB - Genetics and molecular biology

  • CEP - secondary branch

    EE - Microbiology, virology

  • CEP - another secondary branch

    GF - Diseases, pests, weeds and plant protection

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10606 - Microbiology<br>10607 - Virology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>40106 - Agronomy, plant breeding and plant protection; (Agricultural biotechnology to be 4.4)

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    The application of artificial dsRNA molecules derived from the viral cp gene to activate RNA interference against the PSbMV has been investigated. Simultaneous application of dsRNA and virus inoculation or dsRNA application one day before led to the significant short-term decreasing of the PSbMV concentration. The curative effect of the application on PSbMV infected plants was not confirmed.

Solution timeline

  • Realization period - beginning

    Mar 1, 2012

  • Realization period - end

    Mar 31, 2013

  • Project status

    U - Finished project

  • Latest support payment

    Feb 25, 2013

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP14-MSM-LD-U/01:1

  • Data delivery date

    Jun 30, 2014

Finance

  • Total approved costs

    542 thou. CZK

  • Public financial support

    542 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK