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LH15074

Elucidating the mechanism of asymmetric cell division using Xenopus oocytes as model system

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    KONTAKT II

  • Call for proposals

    KONTAKT II 5 (SMSM2015LH5)

  • Main participants

    Biotechnologický ústav AV ČR, v. v. i.

  • Contest type

    VS - Public tender

  • Contract ID

    MSMT-32267/2015-1

Alternative language

  • Project name in Czech

    Objasnění mechanismu asymetrického dělení buněk za pomoci vajíček drápatky jako modelového systému

  • Annotation in Czech

    1. Lokalizaci maternálních RNA a proteinů v animálně–vegetativní ose. 2. Distribuci maternálních RNA a proteinů do jednotlivých buněk ve stádiích 2 až 4-buněčného embrya a určení asymetrické lokalizace v dorsálně–ventrální a pravo–levé ose.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    EB - Genetics and molecular biology

  • CEP - secondary branch

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    We determined global localization of RNAs and protein in Xenopus oocytes and found new class ofextremely animal RNAs. Bioinformatic analysis identified new localization motifs in vegetal RNAs, but none in extremely animal. We showed good correlation in oocyte RNA-protein localization. Other developmental axes (left-right and dorso-ventral) are determined of proteins.

Solution timeline

  • Realization period - beginning

    Oct 1, 2015

  • Realization period - end

    Dec 31, 2017

  • Project status

    U - Finished project

  • Latest support payment

    Mar 2, 2017

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP18-MSM-LH-U/01:1

  • Data delivery date

    Jun 7, 2018

Finance

  • Total approved costs

    1,999 thou. CZK

  • Public financial support

    1,999 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK