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LH15213

Behavior and shape of nanoparticles – anticancer drug carriers in real blood environment.

Project goals

The main aim of the proposal is to investigate the inner structure of nanoparticles composed of tumor-targeted polymer-doxorubicin conjugates in real blood environment. Precise distribution of all entities (cholesterol and drug) will be established.

Keywords

blood; nanoparticlesdrug deliveryblood

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    KONTAKT II

  • Call for proposals

    KONTAKT II 5 (SMSM2015LH5)

  • Main participants

    Ústav makromolekulární chemie AV ČR, v. v. i.

  • Contest type

    VS - Public tender

  • Contract ID

    32267/2015-1

Alternative language

  • Project name in Czech

    Chování a tvar nanočástic – protirakovinných nosičů léčiv ve skutečném prostředí krve.

  • Annotation in Czech

    Hlavním cílem projektu je výzkum vnitřní struktury nanočástic tvořených polymerními konjugáty s doxorubicinem určených protirakovinných nosičů léčiv ve skutečném prostředí krve. Přesná distribuce bude zjištěna pro všechny entity (cholesterol a léčivo).

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    CD - Macromolecular chemistry

  • CEP - secondary branch

    —

  • CEP - another secondary branch

    —

  • 10404 - Polymer science

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    It was found that individual proteins and plasma have very low binding affinity to nanoparticles. Our study suggests that a classical “hard corona-soft corona” paradigm is not valid for all types of nanoparticles but rather represents an extreme case for some types of charged and hydrophobic nanoparticles.

Solution timeline

  • Realization period - beginning

    Oct 13, 2015

  • Realization period - end

    Dec 31, 2017

  • Project status

    U - Finished project

  • Latest support payment

    Mar 2, 2017

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP18-MSM-LH-U/01:1

  • Data delivery date

    Jun 7, 2018

Finance

  • Total approved costs

    2,454 thou. CZK

  • Public financial support

    1,835 thou. CZK

  • Other public sources

    619 thou. CZK

  • Non public and foreign sources

    0 thou. CZK

Basic information

Recognised costs

2 454 CZK thou.

Public support

1 835 CZK thou.

74%

Provider

Ministry of Education, Youth and Sports

CEP

CD - Macromolecular chemistry

Solution period

13. 10. 2015 - 31. 12. 2017

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