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LK11215

Regulation of active endogenous retroviruses in the mammalian genome

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    NAVRAT

  • Call for proposals

    NÁVRAT 1 (SMSM2012LK1)

  • Main participants

    Ústav molekulární genetiky AV ČR, v. v. i.

  • Contest type

    VS - Public tender

  • Contract ID

    MSMT-8056/2012

Alternative language

  • Project name in Czech

    Regulace aktivních endogenních retrovirů v savčím genomu

  • Annotation in Czech

    Objasnění epigenetické regulace na unikátním modelu silně polymorfního savčího endogenního retroviru. Dále genetická a virologická charakterizace tohoto endogenního retroviru. Hledání obdobného polymorfismu u jiných savčích druhů.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    EE - Microbiology, virology

  • CEP - secondary branch

    EE - Microbiology, virology

  • CEP - another secondary branch

    EB - Genetics and molecular biology

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10606 - Microbiology<br>10607 - Virology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    A new model of retrovirus endogenization was established; this retrovirus (CrERV) was virologically and genetically characterized. A novel method for high throughput analysis of retrovirus integration sites was established and applied for their epigenetic analysis. The bioinformatic and genetic screens enabled description of the oldest Lentivirus and the first case of endogenous Deltaretrovirus.

Solution timeline

  • Realization period - beginning

    Sep 1, 2012

  • Realization period - end

    Dec 31, 2016

  • Project status

    U - Finished project

  • Latest support payment

    Jan 28, 2016

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP17-MSM-LK-U/01:1

  • Data delivery date

    Jun 22, 2017

Finance

  • Total approved costs

    14,077 thou. CZK

  • Public financial support

    14,077 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK