Regulation of active endogenous retroviruses in the mammalian genome
Public support
Provider
Ministry of Education, Youth and Sports
Programme
NAVRAT
Call for proposals
NÁVRAT 1 (SMSM2012LK1)
Main participants
Ústav molekulární genetiky AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
MSMT-8056/2012
Alternative language
Project name in Czech
Regulace aktivních endogenních retrovirů v savčím genomu
Annotation in Czech
Objasnění epigenetické regulace na unikátním modelu silně polymorfního savčího endogenního retroviru. Dále genetická a virologická charakterizace tohoto endogenního retroviru. Hledání obdobného polymorfismu u jiných savčích druhů.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
EE - Microbiology, virology
CEP - secondary branch
EE - Microbiology, virology
CEP - another secondary branch
EB - Genetics and molecular biology
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10606 - Microbiology<br>10607 - Virology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
A new model of retrovirus endogenization was established; this retrovirus (CrERV) was virologically and genetically characterized. A novel method for high throughput analysis of retrovirus integration sites was established and applied for their epigenetic analysis. The bioinformatic and genetic screens enabled description of the oldest Lentivirus and the first case of endogenous Deltaretrovirus.
Solution timeline
Realization period - beginning
Sep 1, 2012
Realization period - end
Dec 31, 2016
Project status
U - Finished project
Latest support payment
Jan 28, 2016
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP17-MSM-LK-U/01:1
Data delivery date
Jun 22, 2017
Finance
Total approved costs
14,077 thou. CZK
Public financial support
14,077 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK