Development of technologies for early detection of tick borne encephalitis, based on changes in gene expression and protein production in infected antigen-presenting cells
Public support
Provider
Ministry of Education, Youth and Sports
Programme
INTER-EXCELLENCE
Call for proposals
INTER-EXCELLENCE 12 (SMSM2018LTARF)
Main participants
Biologické centrum AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
MSMT-5727/2018-5
Alternative language
Project name in Czech
Vývoj technologie pro časnou detekci klíšťové encefalitidy založené na změnách v genové expresi a produkci proteinů u antigen-prezentujících buněk
Annotation in Czech
V rámci projektu bude diferencovaná genová exprese a tvorba proteinů analyzována v buňkách prezentujících antigen během infekce virem klíšťové encefalitidy. Diferenciálně exprimované geny a proteiny budou použity pro identifikaci infekce hostitele v časné fázi. Identifikovaný marker bude sloužit k nové možnosti diagnostiky klíšťové encefalitidy u lidí.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10606 - Microbiology
OECD FORD - secondary branch
10607 - Virology
OECD FORD - another secondary branch
—
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EE - Microbiology, virology
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
"Primary immune cells, which get into a contact with the tick-borne encephalitis virus in humans, were prepared – M2 macrophages and Langerhans cells. We described the infection of these cells by the virus and performed proteomic and transcriptomic analyses of these cells as well as infected cells. Identified were several candidates for markers of early infection by the virus."
Solution timeline
Realization period - beginning
Jan 16, 2018
Realization period - end
Dec 31, 2021
Project status
U - Finished project
Latest support payment
Sep 5, 2020
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP22-MSM-LT-U
Data delivery date
Jun 30, 2022
Finance
Total approved costs
7,836 thou. CZK
Public financial support
7,836 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK