Carotenoids and flavonoids: interactions and hybrid antioxidants
Public support
Provider
Ministry of Education, Youth and Sports
Programme
INTER-EXCELLENCE
Call for proposals
INTER-EXCELLENCE 2 (SMSM2016LTC01)
Main participants
Mikrobiologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
MSMT-15304/2017-1
Alternative language
Project name in Czech
Karotenoidy a flavonoidy: interakce a hybridní antioxidanty
Annotation in Czech
Pomocí enzymových metod připravíme hybridní antioxidanty založené na karotenoidech, flavonoidech a vybraných vitamínech. Budou testovány jejich antiradikálové a redoxní aktivity. Budeme studovat metabolismus karotenoidů a jejich interakce s flavonoidy. Ve spolupráci s partnery akce COST budou nové látky testovány v biologických systémech a budou studovány jejich biofyzikální vlastnosti.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
CC - Organic chemistry
CEP - secondary branch
CE - Biochemistry
CEP - another secondary branch
FR - Pharmacology and apothecary chemistry
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10401 - Organic chemistry<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30104 - Pharmacology and pharmacy
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
Esterification method based on a Steglich reaction was developed to produce the carotenoid-flavonoid hybrid antioxidants, i.e. the retinol, dehydrosilybin and silybins hybrids at the C-7 position of silybin and C-7 and C-3 in dehydrosilybin. The substances were characterized (NMR, MS), biophysical tests were completed. Results were published in 9 publications and presented at conferences.
Solution timeline
Realization period - beginning
Jun 1, 2017
Realization period - end
Apr 15, 2020
Project status
U - Finished project
Latest support payment
Feb 24, 2020
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP21-MSM-LT-U/01:1
Data delivery date
Jun 15, 2021
Finance
Total approved costs
2,693 thou. CZK
Public financial support
2,693 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK