In vitro toxicological comparison of extracts of stressed transgenic and non-transgenic crops
Project goals
The aims of this project are: i) High-throughput screening of plant extracts comparing transgenic plant and its counterpart in order to a) evaluate the approaches which were used for genetic manipulation/edition from the toxicological point of view and b) evaluate if the selected genetic manipulation has any effect on toxicological profile of the plant species. ii) High-throughput screening of plant extracts comparing transgenic plant and its counterpart when exposed to stress in order to determine if the GM plants are better prepared to cope with the environmental stressor, synthetize less secondary metabolites and are therefore less toxic.
Keywords
Food and feed qualitytoxicitystressgenetic engineeringtransgenic plants
Public support
Provider
Ministry of Education, Youth and Sports
Programme
INTER-EXCELLENCE
Call for proposals
SMSM2020LTC01
Main participants
Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
Contest type
VS - Public tender
Contract ID
MSMT-21080/2020-9
Alternative language
Project name in Czech
In vitro toxicological comparison of extracts of stressed transgenic and non-transgenic crops
Annotation in Czech
The aims of this project are: i) High-throughput screening of plant extracts comparing transgenic plant and its counterpart in order to a) evaluate the approaches which were used for genetic manipulation/edition from the toxicological point of view and b) evaluate if the selected genetic manipulation has any effect on toxicological profile of the plant species. ii) High-throughput screening of plant extracts comparing transgenic plant and its counterpart when exposed to stress in order to determine if the GM plants are better prepared to cope with the environmental stressor, synthetize less secondary metabolites and are therefore less toxic.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
21101 - Food and beverages
OECD FORD - secondary branch
30304 - Public and environmental health
OECD FORD - another secondary branch
10603 - Genetics and heredity (medical genetics to be 3)
DN - Environmental impact on health
EB - Genetics and molecular biology
FM - Hygiene
GM - Food industry
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Protocols for high-throughput testing of toxicity, especially endocrine disruption and genotoxicity, including metabolic activation, have been validated. These protocols were used for the toxicological assessment of mycotoxins – secondary metabolites of fungi. Transgenic barley, soy and potato were subjected to appropriate stress, their extracts were assessed from the view of safety for consumers.
Solution timeline
Realization period - beginning
Jun 1, 2020
Realization period - end
Mar 31, 2023
Project status
U - Finished project
Latest support payment
Feb 17, 2023
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP24-MSM-LT-U
Data delivery date
Jul 1, 2024
Finance
Total approved costs
4,117 thou. CZK
Public financial support
4,117 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Recognised costs
4 117 CZK thou.
Public support
4 117 CZK thou.
0%
Provider
Ministry of Education, Youth and Sports
OECD FORD
Food and beverages
Solution period
01. 06. 2020 - 31. 03. 2023