Enzymatic preparation of glyconanomaterials
Public support
Provider
Ministry of Education, Youth and Sports
Programme
INTER-EXCELLENCE
Call for proposals
SMSM2020LTC01
Main participants
Mikrobiologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
MSMT-21080/2020-36
Alternative language
Project name in Czech
Enzymatic preparation of glyconanomaterials
Annotation in Czech
Major objective of this project proposal is to prepare rhamnose and rutinose containing glycoconjugates and multivalent structures with the use of advanced chemoenzymatic methods and bring these compounds into the applications in treatment of dermatological problems and diabetic ulcer complications. Rhamnosyl-rich oligo- and polysaccharides proved to be active in inhibiting most of the harmful effects of AGE-products - typically wrinkle formation and they demonstrated a potential to revert or diminish their negative consequences. This effect may be caused by the interaction with the hypothetic α-rhamnose-selective lectins e.g. in keratinocytes. We will prepare new multivalent rhamnose carrying structures based on the presentation of rutinosyl moieties (α-L-Rha(16)-β-D-Glc), which can be attached onto various spacers using enzymatic transglycosylation with recently discovered enzyme rutinosidase. These rhamnosyl neoglycoconjugates will be used for rhamnose lectin search and tested in biological assays for inhibitory activity towards AGE-mediated pathologies.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10608 - Biochemistry and molecular biology
OECD FORD - secondary branch
30104 - Pharmacology and pharmacy
OECD FORD - another secondary branch
30401 - Health-related biotechnology
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
CE - Biochemistry<br>EB - Genetics and molecular biology<br>EI - Biotechnology and bionics<br>FR - Pharmacology and apothecary chemistry
Solution timeline
Realization period - beginning
Jun 1, 2020
Realization period - end
Oct 3, 2023
Project status
K - Ending multi-year project
Latest support payment
Feb 25, 2022
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP23-MSM-LT-R
Data delivery date
Oct 17, 2023
Finance
Total approved costs
3,858 thou. CZK
Public financial support
3,858 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK