Natural polyphenolic compounds for adjunct tumor treatment combined with MDR inhibition
Public support
Provider
Ministry of Education, Youth and Sports
Programme
INTER-EXCELLENCE
Call for proposals
SMSM2020LTC01
Main participants
Mikrobiologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
MSMT-21080/2020-37
Alternative language
Project name in Czech
Natural polyphenolic compounds for adjunct tumor treatment combined with MDR inhibition
Annotation in Czech
The objectives of the present project are to participate to the WG2 of the COST Action CA17104 STRATAGEM by synthesizing, through a rational design, a small library of natural flavonoids and flavonolignans and their derivatives with MDR-inhibiting potential for SAR studies of efficiency to be evaluated in the frame of WG3
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10401 - Organic chemistry
OECD FORD - secondary branch
30104 - Pharmacology and pharmacy
OECD FORD - another secondary branch
10608 - Biochemistry and molecular biology
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
CC - Organic chemistry<br>CE - Biochemistry<br>EB - Genetics and molecular biology<br>FR - Pharmacology and apothecary chemistry
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
New brominated, iodinated and chlorinated derivatives of flavonoids and flavonolignans were prepared. The antioxidant, anti-inflammatory and anti-tumor activity of substances and derivatives and their effect on drug resistance were evaluated. A series of flavonoid derivatives substituted with aryl, heteroaryl, alkyl and boronate substituents was prepared for structure-activity relationship studies
Solution timeline
Realization period - beginning
Jun 1, 2020
Realization period - end
Sep 9, 2022
Project status
U - Finished project
Latest support payment
Feb 24, 2022
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP23-MSM-LT-U
Data delivery date
Jun 30, 2023
Finance
Total approved costs
4,132 thou. CZK
Public financial support
4,132 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK