Molecular characterization of autoimmune polyglandular syndromes
Project goals
It is the goal of the submitted project to investigate a possible link of genetic predisposition and immunological features in autoimmune polyglandular syndromes (APS). One important question is whether or not clinically silent and overt forms of APS canbe differentiated by their genetic predisposition. The immunological studies will focus on both B- and T-cell mediated autoimmune responses. A broad range of recombinant antigens that were generated at IPM, Hamburg, can be used for a sensitive and specific diagnosis of APS. Because the T-cell mediated autoimmune response is crucial for the pathogenesis of APS the recombinant proteins also can be used for detection of autoreactive T-cells and the Th1/Th2-balance can be determined by ultrasensitive RT-PCR. Eventually, the specific detection of autoreactive T cells might have a great impact on future treatment of the autoimmune disease already in the subclinical state.
Keywords
autoimmune polyglandular syndromgenetic predispositionTh1/Th2-balance
Public support
Provider
Ministry of Education, Youth and Sports
Programme
KONTAKT
Call for proposals
KONTAKT 1 (SMSM200132001)
Main participants
Endokrinologický ústav
Contest type
VS - Public tender
Contract ID
—
Alternative language
Project name in Czech
Molekulární charakteristika autoimunitního poplyglandulálního syndromu
Annotation in Czech
Cílem předloženého projektu je zjistit možnou vazbu mezi genedickou predizpozicí a rozvojem imunopatologických znaků u autoimunitního polyglandulárního syndromu (APS). Jednou z hlavních otázek je zda klinicky rozvinutý a nerozvinutý APS může mít odlišnosti v genetické predizpozici. Imunologické studie se zaměří na význam B a T lymfocytů v autoimunitním procesu.
Scientific branches
R&D category
—
CEP classification - main branch
FB - Endocrinology, diabetology, metabolism, nutrition
CEP - secondary branch
FN - Epidemiology, infection diseases and clinical immunology
CEP - another secondary branch
FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry
30202 - Endocrinology and metabolism (including diabetes, hormones)
30206 - Otorhinolaryngology
30207 - Ophthalmology
30208 - Dentistry, oral surgery and medicine
30302 - Epidemiology
30303 - Infectious Diseases
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
Exprese HLA antigenů ukazuje na genetickou rozdílnost mezi izolovanou autoimunitní tyreoiditidou a oběma skupinami s polyglandulárními projevy.
Solution timeline
Realization period - beginning
Jan 1, 2000
Realization period - end
Jan 1, 2002
Project status
U - Finished project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP/2003/MSM/MSM3ME/U/N/8:4
Data delivery date
May 22, 2009
Finance
Total approved costs
1,510 thou. CZK
Public financial support
880 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
750 thou. CZK
Recognised costs
1 510 CZK thou.
Public support
880 CZK thou.
0%
Provider
Ministry of Education, Youth and Sports
CEP
FB - Endocrinology, diabetology, metabolism, nutrition
Solution period
01. 01. 2000 - 01. 01. 2002