Novel methylation of Hexim1 and cyclin composition of positive trancription elongation factor b (P-TEFb) regulate kinase activity of cdk9
Public support
Provider
Ministry of Education, Youth and Sports
Programme
KONTAKT
Call for proposals
KONTAKT 7 (SMSM2009ME4)
Main participants
—
Contest type
VS - Public tender
Contract ID
2060/2011-320
Alternative language
Project name in Czech
Nový typ metylace Heximu1 a cyklinové složení positivního transkripčního elongačního faktoru b (P-TEFb) regulují kinázovou aktivitu cdk9
Annotation in Czech
Popis regulace kinázové aktivity cdk9, charakterizace nové postranslační modifikace proteinu - metylace glutamové kyseliny, identifikace příslušné metyltransferázy, definice složení proteinových komplexů cyklinu T1, T2 a K.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
EB - Genetics and molecular biology
CEP - secondary branch
EB - Genetics and molecular biology
CEP - another secondary branch
EB - Genetics and molecular biology
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
We clerified a new regulation of P-TEFb complex; the finding that Cycklin K is not part of P-TEFb complex, but associates with Cdk12, defined new protein complex regulating activity of RNA polymerase II
Solution timeline
Realization period - beginning
Apr 1, 2009
Realization period - end
Dec 31, 2012
Project status
U - Finished project
Latest support payment
Feb 23, 2012
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP13-MSM-ME-U/01:1
Data delivery date
Jun 28, 2013
Finance
Total approved costs
3,247 thou. CZK
Public financial support
2,224 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
2,667 thou. CZK