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ME10011

Trypsin-like proteases from human parasite, blood fluke Schistosoma mansoni

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    KONTAKT

  • Call for proposals

    KONTAKT 8 (SMSM2010ME5)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    2062/2011-320

Alternative language

  • Project name in Czech

    Proteázy trypsinového typu z lidského parazita, krevní motolice Schistosoma mansoni

  • Annotation in Czech

    Charakterizace trypsinových proteáz ze Schistosoma mansoni pomocí: molekulárně biologických analýz, rekombinantní exprese, protilátek, proteolyticky aktivních rekombinantů, biochemických metod.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    FN - Epidemiology, infection diseases and clinical immunology

  • CEP - secondary branch

    CE - Biochemistry

  • CEP - another secondary branch

    EB - Genetics and molecular biology

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30302 - Epidemiology<br>30303 - Infectious Diseases

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    Specific active site probes on the base of 4-chloro-isocoumarin and chloromethyl keton were applied. Evaluation of RNAi effect finalized and in vivo screen based on it is ongoing in the partner laboratory in the USA. Novel patented substrate library wasemployed for screens. Basic recombinant protein expressions finalized. Outputs: Conference presentations and publication before the submission.

Solution timeline

  • Realization period - beginning

    May 1, 2010

  • Realization period - end

    Dec 31, 2012

  • Project status

    U - Finished project

  • Latest support payment

    Feb 16, 2012

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP13-MSM-ME-U/01:1

  • Data delivery date

    Jun 28, 2013

Finance

  • Total approved costs

    2,400 thou. CZK

  • Public financial support

    2,400 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK