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ME10036

Effects of convective transport on chemical signal propagation in living tissues

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    KONTAKT

  • Call for proposals

    KONTAKT 8 (SMSM2010ME5)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    2062/2011-320

Alternative language

  • Project name in Czech

    Vliv konvektivního toku na šíření chemického signálu v živých tkáních

  • Annotation in Czech

    Budou sestaveny a chemicko-inženýrskými technikami analyzovány matematické modely vlivu konvektivního toku na přenos chemického signálu v živé tkáni. V rámci mezinárodní spolupráce budou činěny obecně platné závěry o povaze této mezibuněčné komunikace.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    CI - Industrial chemistry and chemical engineering

  • CEP - secondary branch

    BO - Biophysics

  • CEP - another secondary branch

    BK - Liquid mechanics

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10305 - Fluids and plasma physics (including surface physics)<br>10610 - Biophysics<br>20401 - Chemical engineering (plants, products)<br>20402 - Chemical process engineering

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    A general study on the effects of convective flow on the chemical signal propagation mediated by growth factors above a simple epithelium was published. We also found that oscillatory character of flow leads to the acceleration of signal propagation. With the use of the stoichiometric network analysis method, a reaction core responsible for emergence of bistabilities in MAPK cascade was revealed.

Solution timeline

  • Realization period - beginning

    May 1, 2010

  • Realization period - end

    Dec 31, 2012

  • Project status

    U - Finished project

  • Latest support payment

    Feb 16, 2012

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP13-MSM-ME-U/01:1

  • Data delivery date

    Jun 28, 2013

Finance

  • Total approved costs

    1,768 thou. CZK

  • Public financial support

    1,768 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK