A biomechanical evaluation of stability in spine injuries after augmentation with an injectable, in situ hardening hydroxyapatite (NORIAN)
Project goals
In an experimental trial on porcine specimen will be evaluated the flexional (anterior) loading on an injured spine segment, augmented with an injectable, in situ setting, hardening carbonated apatite. In a prospective clinical evaluation it will be followed-up the postoperative loss of correction in selected type A thoracolumbar spine instabilities, augmented with an injectable, in situ setting, hardening carbonated apatite. The application will be provided minimally invasively, percutanneously.
Keywords
hydroxylapatitintervertabrální biokeramikaklasifikaceNorian SRSpáteřní fixátoryperkutanníPLIFstabilizace
Public support
Provider
Ministry of Health
Programme
Research and development in the sphere or surgery
Call for proposals
—
Main participants
Úrazová nemocnice v Brně
Contest type
VS - Public tender
Contract ID
—
Alternative language
Project name in Czech
Biomechanická studie o stabilitě poraněného bederního obratle, augmentovaného rychle tuhnoucí biokeramikou (NORIAN SRS)
Annotation in Czech
V experimentu bude vyzkoumána flekční zátěž poraněného páteřního segmentu, augmentovaného rychle tuhnoucí tekutou biokeramickou látkou. Látka bude aplikována do intervertebrálního prostoru po vyjmutí intervertebrální ploténky. Vazové spojení zůstává. V prospektivní klinické studii bude sledována schopnost augmentace nové niokeramické látky. Ztráta poúrazové korekce lze měřit na boční rtg projekci pomocí geometrického měření. Schopnost rychlé tuhnutí látky ušetří nákladnou stabilizaci páteře.
Scientific branches
R&D category
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CEP classification - main branch
FI - Traumatology and orthopaedics
CEP - secondary branch
FH - Neurology, neuro-surgery, nuero-sciences
CEP - another secondary branch
EI - Biotechnology and bionics
20801 - Environmental biotechnology
20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management
20803 - Environmental biotechnology related ethics
20901 - Industrial biotechnology
20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
30103 - Neurosciences (including psychophysiology)
30210 - Clinical neurology
30211 - Orthopaedics
30401 - Health-related biotechnology
30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])
30404 - Biomaterials (as related to medical implants, devices, sensors)
30405 - Medical biotechnology related ethics
40401 - Agricultural biotechnology and food biotechnology
40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming
40403 - Agricultural biotechnology related ethics
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Náhražka s užitím metylmetakrylátových kostních cementů nemůže nahradit bioaktivní materiál. Publ.: 3x - nejvýznamnější Interbody Fusion in Thoracolumbar Fractures.
Solution timeline
Realization period - beginning
Jan 1, 1999
Realization period - end
Jan 1, 2001
Project status
U - Finished project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP/2002/MZ0/MZ02ND/U/N/6:2
Data delivery date
Mar 23, 2004
Finance
Total approved costs
2,472 thou. CZK
Public financial support
2,432 thou. CZK
Other public sources
41 thou. CZK
Non public and foreign sources
0 thou. CZK
Basic information
Recognised costs
2 472 CZK thou.
Public support
2 432 CZK thou.
98%
Provider
Ministry of Health
CEP
FI - Traumatology and orthopaedics
Solution period
01. 01. 1999 - 01. 01. 2001