Treatment of deep chondral defects with autologous chondrocyte implantation on porous matrices
Project goals
The project investigates possibilities of chondral defect treatment with autologous chondrocyt implantation on a porous matrix ( hyaluronic ac., collagen). Histologic, imunohistologic and mechanical features of the newly formed cartilage are investigatedThe clinical benefit of the method is evaluated in a prospective study.
Keywords
implantationautologous chondrocyteshyaline cartilagechondral defectshistologymechanical propertiesporous matrix
Public support
Provider
Ministry of Health
Programme
Research and development in the sphere or surgery
Call for proposals
Výzkum a vývoj v oblasti Kardiovaskulárních chorob 11 (SMZ02003ND)
Main participants
Institut postgraduálního vzdělávání ve zdravotnictví
Contest type
VS - Public tender
Contract ID
—
Alternative language
Project name in Czech
Ošetření hlubokých defektů kloubní chrupavky transplantací autologních chondrocytů na pevném nosiči
Annotation in Czech
Projekt ověřuje možnosti ošetření chondrálních defektů transplantací autologních chondrocytů na pevném nosiči (kys.hyaluronová, kolagen). U novotvořené chrupavky posuzuje její histologické, imunohistologické a mechanické vlastnosti.
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
FI - Traumatology and orthopaedics
CEP - secondary branch
FJ - Surgery including transplantology
CEP - another secondary branch
—
30211 - Orthopaedics
30212 - Surgery
30213 - Transplantation
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Functional improvement in the knee could be followed in all patients.Hyalograft C leads to formation of new cartilage at dhe defect site.Well-fixed tissue of a mainly mixed type formed in less than a year.The scaffold carrier resorbed without problems.
Solution timeline
Realization period - beginning
Jan 1, 2003
Realization period - end
Jan 1, 2005
Project status
U - Finished project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP06-MZ0-ND-U/01:1
Data delivery date
Jun 23, 2006
Finance
Total approved costs
4,539 thou. CZK
Public financial support
4,165 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Recognised costs
4 539 CZK thou.
Public support
4 165 CZK thou.
0%
Provider
Ministry of Health
CEP
FI - Traumatology and orthopaedics
Solution period
01. 01. 2003 - 01. 01. 2005