Hybrid gene TEL/AML1 and Asparagine Synthetase gene in pathogenesis of childhood leukemias.
Public support
Provider
Ministry of Health
Programme
Research and development in the sphere of paediatrics and genetics
Call for proposals
Výzkum a vývoj v oblasti Kardiovaskulárních chorob 14 (SMZ02003NE)
Main participants
Univerzita Karlova / 2. lékařská fakulta
Contest type
VS - Public tender
Contract ID
—
Alternative language
Project name in Czech
Hybridní gen TEL/AML1 a gen pro asparagin synthetasu v patogenesi dětských leukemií
Annotation in Czech
Navrhovaná studie se zaměří na vztrah mezi hybridním genem TEL/AML1, L-asparaginasou a regulací genu pro asparagin synthetasu v leukemických buńkách. Budeme využívat moderní přístupy včetně kvantitativní PCR v reálném čase a RNA interference. Budeme studovat mechanismy regulace exprese asparagin synthetasy, aktivitu asparagin synthetasy, vztah mezi TEL/AML1 a expresí asparagin synthetasy a resistencí na L-asparaginasu.
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
EB - Genetics and molecular biology
CEP - secondary branch
FD - Oncology and haematology
CEP - another secondary branch
FG - Paediatrics
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30204 - Oncology<br>30205 - Hematology<br>30209 - Paediatrics
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
Different intracellular synthesis of asparagine and glutamine in TEL/AML1(+) cells causes better sensitivity to L-Asparaginase.This divergence is manifested by defferent gene expression of Asparagin Synthetase and Glutamate Dehydrogenase.
Solution timeline
Realization period - beginning
Jan 1, 2003
Realization period - end
Jan 1, 2005
Project status
U - Finished project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP06-MZ0-NE-U/02:1
Data delivery date
Jun 23, 2006
Finance
Total approved costs
3,299 thou. CZK
Public financial support
3,284 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK