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NF7576

Evaluation of lateralisation of nitric oxide mediator system in the hippocampus of people with schizophrenia and Alzheimer disease

Public support

  • Provider

    Ministry of Health

  • Programme

    Research and development in the sphere of neurology and psychiatry

  • Call for proposals

    Výzkum a vývoj v oblasti Kardiovaskulárních chorob 17 (SMZ02003NF)

  • Main participants

    Národní ústav duševního zdraví

  • Contest type

    VS - Public tender

  • Contract ID

Alternative language

  • Project name in Czech

    Testování lateralizace mediátorového systému oxidu dusnatého v hipokampu lidí se schizofrenií a Alzheimerovou nemocí

  • Annotation in Czech

    V pravém a levém hipokampu lidí se schizofrenií, Alzheimerovou nemocí a multi-infarktovou demencí bude stanovena exprese a aktivita jednotlivých syntáz oxidu dusnatého a koncentrace L-glutamátu, L-argininu, L-citrulinu, dusičnanů a dusitanů. Bude vyhodnocena lateralita mediátorového systému oxidu dusnatého u zdravých lidí a srovnána s odchylkami nedementních psychiatrických a dementních pacientů.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    ED - Physiology

  • CEP - secondary branch

    FH - Neurology, neuro-surgery, nuero-sciences

  • CEP - another secondary branch

    FL - Psychiatry, sexology

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30103 - Neurosciences (including psychophysiology)<br>30105 - Physiology (including cytology)<br>30210 - Clinical neurology<br>30215 - Psychiatry<br>30301 - Social biomedical sciences (includes family planning, sexual health, psycho-oncology, political and social effects of biomedical research)

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Antagonistic alterations i laterality of hippocampal nitric syst. were observes in people with Alzheimer disease and schizophrenia.Volumetry of planum temporale indicated lateral changes in demented and only bilateral in schizophrenic groups.

Solution timeline

  • Realization period - beginning

    Jan 1, 2003

  • Realization period - end

    Jan 1, 2005

  • Project status

    U - Finished project

  • Latest support payment

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP06-MZ0-NF-U/01:1

  • Data delivery date

    Jun 23, 2006

Finance

  • Total approved costs

    5,364 thou. CZK

  • Public financial support

    5,257 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK