Hepatic stellate cells scintigraphy as a marker of early liver fibrosis
Public support
Provider
Ministry of Health
Programme
Branch programm of research of the Ministry of Health
Call for proposals
VaV pro Ministerstvo zdravotnictví 1 (SMZ02004NR)
Main participants
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Contest type
VS - Public tender
Contract ID
—
Alternative language
Project name in Czech
Scintigrafie hvězdicových buněk jako časný marker jaterní fibrózy
Annotation in Czech
Budou syntetizovány izotopově značené sloučeniny pro scintigrafickou detekci transformace hvězdicových buněk v časném stádiu jaterní fibrózy. Použitelnost sloučenin pro scintigrafii bude testována na zvířecích modelech jaterní fibrózy.
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
FE - Other fields of internal medicine
CEP - secondary branch
FR - Pharmacology and apothecary chemistry
CEP - another secondary branch
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
30104 - Pharmacology and pharmacy<br>30202 - Endocrinology and metabolism (including diabetes, hormones)<br>30217 - Urology and nephrology<br>30218 - General and internal medicine<br>30219 - Gastroenterology and hepatology<br>30220 - Andrology
Completed project evaluation
Provider evaluation
S - Nesplněno zadání, bylo přistoupeno k sankčním ustanovením smlouvy
Project results evaluation
Two novel derivatives of retinol were synthesized and characterized and their kinetics after intravenous injection was studied in an animal model. Contraty to expected behaviour the compounds were not suitable for scintigraphy of liver stellate cells.
Solution timeline
Realization period - beginning
Jan 1, 2004
Realization period - end
Jan 1, 2006
Project status
S - Stopped (prematurely terminated) multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP07-MZ0-NR-U/06:2
Data delivery date
Aug 8, 2007
Finance
Total approved costs
1,895 thou. CZK
Public financial support
1,827 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
54 thou. CZK