Determination of Pentosidinine in Etiopathogenesis of Rheumatic and Diabetic Diseases and Influence of its Level by the Medication with Vitamin C in Glycation and Oxidation Stress of the Organism

Provider

Ministry of Health

Programme

Branch programm of research of the Ministry of Health

Call for proposals

VaV pro Ministerstvo zdravotnictví 1 (SMZ02004NR)

Main participants

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Contest type

VS - Public tender

Contract ID

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Project name in Czech

Stanovení pentosidinu v etiopatogenezi revmatických a diabetických onemocnění a ovlivnění jeho hladiny podáváním vitaminu C při glykační a oxidační zátěži organismu

Annotation in Czech

HPLC stanovení pentosidinu (produktu pokročilé glykace) tvořeného v organismu při artritidě a diabetu mellitu. Uplatnění pentosidinu jako indikátoru glykační a oxidační zátěže a vliv vitaminu C na inhibici glykoxidačních procesů - in vivo experiment.

R&D category

NV - Nonindustrial research (Applied research excluded Industrial research)

CEP classification - main branch

FP - Other medical fields

CEP - secondary branch

FB - Endocrinology, diabetology, metabolism, nutrition

CEP - another secondary branch

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OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30202 - Endocrinology and metabolism (including diabetes, hormones)<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science

Provider evaluation

V - Vynikající výsledky projektu (s mezinárodním významem atd.)

Project results evaluation

HPLC determination of PEN confirmed contribution of inflammation, glycoxidation and age to accumulation of AGEs in body fluids and tissue in active arthritis and diabetes. There is no evidence of the influence of vitamin C in inhibition of PEN formation

Realization period - beginning

Jan 1, 2004

Realization period - end

Jan 1, 2006

Project status

U - Finished project

Latest support payment

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Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP07-MZ0-NR-U/06:2

Data delivery date

Aug 8, 2007

Total approved costs

1,741 thou. CZK

Public financial support

1,727 thou. CZK

Other public sources

0 thou. CZK

Non public and foreign sources

9 thou. CZK