Apoptosis in osteoarthritis: Investigation of the expression of apoptosi modulating molecules and the presence of cell death in OA joint tissues.
Public support
Provider
Ministry of Health
Programme
Branch programm of research of the Ministry of Health
Call for proposals
VaV pro Ministerstvo zdravotnictví 1 (SMZ02004NR)
Main participants
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Contest type
VS - Public tender
Contract ID
—
Alternative language
Project name in Czech
Osteoartritida a apoptóza: Exprese molekul ovlivňujících apoptózu ve vztahu k přítomnosti buněčné smrti v OA synoviální membráně a chrupavce.
Annotation in Czech
Synovie a kost se mohou produkcí cytokinů nebo faktorů způsobujících apoptózu podílet na degradaci chrupavky. Chtěli bychom zkoumat expresi a molekul spojených s apoptózou a výskyt apoptózy v OA synoviální membráně a chrupavce. Experimenty budou prováděny za použití metod imunohistochemie, in situ hybridizace, ELISA a siRNA.
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
FP - Other medical fields
CEP - secondary branch
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CEP - another secondary branch
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OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Determ. of antiapoptotic molecule bcl2 and proapoptotic molecules bax, trail, p53 in OA cartilage. Apoptosis of chondrocytes in process of OA induced by extracell. stimuli as the molecules which can be produced by synovial membrane, bone or chondrocytes
Solution timeline
Realization period - beginning
Jan 1, 2004
Realization period - end
Jan 1, 2006
Project status
U - Finished project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP07-MZ0-NR-U/06:2
Data delivery date
Aug 8, 2007
Finance
Total approved costs
2,570 thou. CZK
Public financial support
2,551 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK