Genetic basis of syndrome MIA (Malnutrition - Inflammation - Atherosclerosis) - complication of hemodialysis treatment
Public support
Provider
Ministry of Health
Programme
Branch programm of research of the Ministry of Health
Call for proposals
VaV pro Ministerstvo zdravotnictví 1 (SMZ02004NR)
Main participants
—
Contest type
VS - Public tender
Contract ID
NR7958-5/2004
Alternative language
Project name in Czech
Genetická podstata komplikace hemodialyzační léčby - syndromu MIA (Malnutrition-Inflammation-Atherosclerosis)
Annotation in Czech
Charakterizovat na pacientech s chronickým renálním selháním a MIA syndromem frekvence alel a genotypů genů pro ghrelin, LBP a HFE a zjistit, zda se liší od výskytu alel v populaci. Zjistit, jak varianty genů pro ghrelin, LBP a HFE ovlivní komplikace hemodialyzační léčby a incidenci kardiovaskulárních onemocnění u pacientů s chronickým renálním selháním a MIA syndromem.
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
EB - Genetics and molecular biology
CEP - secondary branch
FA - Cardiovascular diseases including cardio-surgery
CEP - another secondary branch
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30201 - Cardiac and Cardiovascular systems<br>30202 - Endocrinology and metabolism (including diabetes, hormones)
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
Altogether 16 variants in 8 genes were analyzed as putative risk factors for renal failure and/or hemodialysis complications. Renal failure was associated with variants APOE, HFE, FTO, MTHFR. Ghrelin variants had effect on cholesterol a BMI development.
Solution timeline
Realization period - beginning
Jan 1, 2004
Realization period - end
Dec 31, 2008
Project status
U - Finished project
Latest support payment
Mar 5, 2008
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP09-MZ0-NR-U/09:2
Data delivery date
Apr 27, 2011
Finance
Total approved costs
4,136 thou. CZK
Public financial support
3,810 thou. CZK
Other public sources
131 thou. CZK
Non public and foreign sources
0 thou. CZK