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NR7984

An effect of HLA-DP incompatibilities on the outcome of hematopoietic stem cell transplantation.

Public support

  • Provider

    Ministry of Health

  • Programme

    Branch programm of research of the Ministry of Health

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví 1 (SMZ02004NR)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

Alternative language

  • Project name in Czech

    Vliv inkompatibilit v DP genech na úspěch transplantací hematopoetických kmenových buněk

  • Annotation in Czech

    Studium vlivu HLA-DP genů na transplantace hematopoetických kmenových buněk (HSCT). Porovnání neshod mezi pacientem a nepříbuzným dárcem v HLA-DP s parametry úspěšnosti transplantace. Úprava standardního protokolu vyhledávání nepříbuzných dárců HSC: zavedení metody Sequence-Based Typing, v indikovaných případech rutinní genotypizace HLA-DP touto metodou.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FJ - Surgery including transplantology

  • CEP - secondary branch

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30212 - Surgery<br>30213 - Transplantation

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    Project confirmed high level of mismatches of HLA-DPB1 gene between patients and their HSC donors. The search for match in HLA_DPB1 locus is not acceptable. The method of direct sequencing for HLA typing was implemented to the standard search protocol.

Solution timeline

  • Realization period - beginning

    Jan 1, 2004

  • Realization period - end

    Jan 1, 2006

  • Project status

    U - Finished project

  • Latest support payment

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP07-MZ0-NR-U/06:2

  • Data delivery date

    Aug 8, 2007

Finance

  • Total approved costs

    3,415 thou. CZK

  • Public financial support

    3,298 thou. CZK

  • Other public sources

    7 thou. CZK

  • Non public and foreign sources

    0 thou. CZK