Analysis of QT dynamicity behaviour in relationship to the risk of sudden cardiac death
Project goals
Changes of cardiomyocytes repolarization, expressed by changes of QT interval duration, are related to an increased risk of malignant ventricular arrhythmias. A modern way to describe QT interval behaviour is QT dynamicity - QT/RR relationship. The project assess QT dynamicity in relationship to a risk of malignant ventricular arrhythmias and sudden death. The pacients with long QT syndrome and patients with ICD - survivors of sudden death - are used as control groups.
Keywords
QT dynamicitysudden cardiac deathQT intervallong QT syndromeholter monitoringrepolarization
Public support
Provider
Ministry of Health
Programme
Branch programm of research of the Ministry of Health
Call for proposals
VaV pro Ministerstvo zdravotnictví 1 (SMZ02004NR)
Main participants
—
Contest type
VS - Public tender
Contract ID
—
Alternative language
Project name in Czech
Analýza chování QT dynamicity ve vztahu k riziku náhlé srdeční smrti
Annotation in Czech
Změny repolarizace kardiomyocytů, vyjádřené změnou trvání QT intervalu, jsou spojeny se zvýšeným rizikem maligních komorových arytmií. Moderním způsobem popisu chování QT intervalu je QT dynamicita - závislost QT intervalu na RR intervalu. Projekt hodnotí QT dynamicitu ve vztahu k riziku maligních komorových arytmií a náhlé smrti. Jako kontrolní soubory slouží pacienti se syndromem dlouhého QT intervalu a jedinci s ICD, kteří přežili náhlou smrt.
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
FA - Cardiovascular diseases including cardio-surgery
CEP - secondary branch
EB - Genetics and molecular biology
CEP - another secondary branch
—
10603 - Genetics and heredity (medical genetics to be 3)
10604 - Reproductive biology (medical aspects to be 3)
10605 - Developmental biology
10608 - Biochemistry and molecular biology
10609 - Biochemical research methods
30101 - Human genetics
30201 - Cardiac and Cardiovascular systems
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
The study showes the limitation of QT dynamicity as risk stratification test in different heart diseases. It seems likely that the time-dependant changes ant the influence of different factors can improve the prognostic predictive value of test.
Solution timeline
Realization period - beginning
Jan 1, 2004
Realization period - end
Jan 1, 2006
Project status
U - Finished project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP07-MZ0-NR-U/06:2
Data delivery date
Aug 8, 2007
Finance
Total approved costs
1,095 thou. CZK
Public financial support
1,042 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Basic information
Recognised costs
1 095 CZK thou.
Public support
1 042 CZK thou.
95%
Provider
Ministry of Health
CEP
FA - Cardiovascular diseases including cardio-surgery
Solution period
01. 01. 2004 - 01. 01. 2006