The effect of histone deacetylase inhibitors on TEL/AML1 - positive leukaemic cells
Public support
Provider
Ministry of Health
Programme
Branch programm of research of the Ministry of Health
Call for proposals
VaV pro Ministerstvo zdravotnictví 2 (SMZ02005NR)
Main participants
—
Contest type
VS - Public tender
Contract ID
NR8316-3/2005
Alternative language
Project name in Czech
Vliv inhibitorů deacetylas histonů na TEL/AML1 positivní leukemické buňky
Annotation in Czech
Pomocí inhibitorů deacetylas histonů způsobíme remodelaci chromatinu vedoucí k apoptose a diferenciaci TEL/AML1 positivních leukemických buněk. Budeme in vitro analysovat vliv této léčby na změny buněčného cyklu a genové exprese v leukemických buňkách.
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
EB - Genetics and molecular biology
CEP - secondary branch
FD - Oncology and haematology
CEP - another secondary branch
FG - Paediatrics
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30204 - Oncology<br>30205 - Hematology<br>30209 - Paediatrics
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
New knowledge for hematology, treatment of ALL and explanation of HDACi effects. Apoptosis and cell cycle by using HDACi was proved in cells with TEL/AML1 Other genes sharing on the regulation of proliferation and dif of TEL/AML1 cells have been found.
Solution timeline
Realization period - beginning
Jan 1, 2005
Realization period - end
Dec 31, 2007
Project status
U - Finished project
Latest support payment
Mar 2, 2007
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP08-MZ0-NR-U/03:1
Data delivery date
Sep 16, 2008
Finance
Total approved costs
3,877 thou. CZK
Public financial support
3,834 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
5 thou. CZK