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NR9075

Immunotherapy of chronic myeloid leukemia: Development and testing of experimental vaccines in mouse model and immunological study in CML patients

Project goals

The aim of the project proposed is to test the immunogenicity of genetic and peptide vaccines both individually and in different combinations as well as in combination with chemotherapy. The aim is also to propose a therapeutic vaccine suitable to be used in human patients. In parallel, a prospective clinical study will aim to determine the immune profile of CML patients and its changes in the course of the disease.

Keywords

leukemiaimmunotherapyvaccineCMLimmunitybcr-abl

Public support

  • Provider

    Ministry of Health

  • Programme

    Branch programm of research of the Ministry of Health

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví 3 (SMZ02006NR)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NR9075-3/2006

Alternative language

  • Project name in Czech

    Imunoterapie chronické myeloidní leukemie: vývoj a testování experimentálních vakcím v myším systému a imunologická studie pacientů

  • Annotation in Czech

    Cílem projektu je prověřit imunogennost několika typů genetických a peptidových vakcín , a to samostatně, v různých kombinacích a rovněž v kombinaci s chemoterapií, a posléze navrhnout terapeutickou vakcínu vhodnou pro humánní aplikaci. Cílem prospektivní klinické studie bude určit imunologický profil pacientů s CML a jeho proměny v průběhu nemoci.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FD - Oncology and haematology

  • CEP - secondary branch

  • CEP - another secondary branch

  • 30204 - Oncology
    30205 - Hematology

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    The results of this project will be used in the furure development of anti-WT-1 vaccines and immunotherapy against CML

Solution timeline

  • Realization period - beginning

    Jan 1, 2006

  • Realization period - end

    Dec 31, 2008

  • Project status

    U - Finished project

  • Latest support payment

    Mar 5, 2008

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP09-MZ0-NR-U/09:2

  • Data delivery date

    Apr 27, 2011

Finance

  • Total approved costs

    20,075 thou. CZK

  • Public financial support

    19,330 thou. CZK

  • Other public sources

    745 thou. CZK

  • Non public and foreign sources

    0 thou. CZK

Basic information

Recognised costs

20 075 CZK thou.

Public support

19 330 CZK thou.

96%


Provider

Ministry of Health

CEP

FD - Oncology and haematology

Solution period

01. 01. 2006 - 31. 12. 2008