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NR9106

The role of NK and NKT cells in the pathogenesis of primary idiopathic polymyositis and dermatomyositis

Public support

  • Provider

    Ministry of Health

  • Programme

    Branch programm of research of the Ministry of Health

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví 3 (SMZ02006NR)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NR9106-3/2006

Alternative language

  • Project name in Czech

    Role NK a NKT buněk v patogenezi primární idiopatické polymyozitidy a dermatomyozitidy

  • Annotation in Czech

    Charakterizace a diferenciace subpopulací NK a NKT buněk v periferní krvi pacientů s PM a DM a periferní krve kontrol. Analýza cytotoxické aktivity a produkce cytokinů (IFNgamma, IL-5, granzym B) ve zjištěných NK/NKT subpopulacích periferní krve pacientůs PM/DM a kontrol.Analýza exprese izoforem CD1d mRNA v buňkách periferní krve pacientů s DM/PM a zdravých kontrol. Korelace dat s klinickými údaji a aktivitou PM/DM, vliv terapie na složení subpopulací NK a NKT buněk. Závěry vyvozené z výsledků by mohlyobjasnit, zda existují subpoplace NK/NKT buněk specifické pro PM nebo DM, a zda je autoimunitní stav výsledkem abrantní funkce těchto buněk.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FP - Other medical fields

  • CEP - secondary branch

    FN - Epidemiology, infection diseases and clinical immunology

  • CEP - another secondary branch

    FE - Other fields of internal medicine

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30217 - Urology and nephrology<br>30218 - General and internal medicine<br>30219 - Gastroenterology and hepatology<br>30220 - Andrology <br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30302 - Epidemiology<br>30303 - Infectious Diseases<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    The study proved that NK a NKT cells play a significant role in the pathogenesis of dermato- and polymyositis, most significant is findings that in these pts is diminuished the cytotoxic activity of NKG2D1CD3-CD56+Nk cells

Solution timeline

  • Realization period - beginning

    Jan 1, 2006

  • Realization period - end

    Dec 31, 2008

  • Project status

    U - Finished project

  • Latest support payment

    Mar 5, 2008

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP09-MZ0-NR-U/09:2

  • Data delivery date

    Apr 27, 2011

Finance

  • Total approved costs

    4,797 thou. CZK

  • Public financial support

    4,539 thou. CZK

  • Other public sources

    258 thou. CZK

  • Non public and foreign sources

    0 thou. CZK