The role of NK and NKT cells in the pathogenesis of primary idiopathic polymyositis and dermatomyositis
Public support
Provider
Ministry of Health
Programme
Branch programm of research of the Ministry of Health
Call for proposals
VaV pro Ministerstvo zdravotnictví 3 (SMZ02006NR)
Main participants
—
Contest type
VS - Public tender
Contract ID
NR9106-3/2006
Alternative language
Project name in Czech
Role NK a NKT buněk v patogenezi primární idiopatické polymyozitidy a dermatomyozitidy
Annotation in Czech
Charakterizace a diferenciace subpopulací NK a NKT buněk v periferní krvi pacientů s PM a DM a periferní krve kontrol. Analýza cytotoxické aktivity a produkce cytokinů (IFNgamma, IL-5, granzym B) ve zjištěných NK/NKT subpopulacích periferní krve pacientůs PM/DM a kontrol.Analýza exprese izoforem CD1d mRNA v buňkách periferní krve pacientů s DM/PM a zdravých kontrol. Korelace dat s klinickými údaji a aktivitou PM/DM, vliv terapie na složení subpopulací NK a NKT buněk. Závěry vyvozené z výsledků by mohlyobjasnit, zda existují subpoplace NK/NKT buněk specifické pro PM nebo DM, a zda je autoimunitní stav výsledkem abrantní funkce těchto buněk.
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
FP - Other medical fields
CEP - secondary branch
FN - Epidemiology, infection diseases and clinical immunology
CEP - another secondary branch
FE - Other fields of internal medicine
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30217 - Urology and nephrology<br>30218 - General and internal medicine<br>30219 - Gastroenterology and hepatology<br>30220 - Andrology <br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30302 - Epidemiology<br>30303 - Infectious Diseases<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
The study proved that NK a NKT cells play a significant role in the pathogenesis of dermato- and polymyositis, most significant is findings that in these pts is diminuished the cytotoxic activity of NKG2D1CD3-CD56+Nk cells
Solution timeline
Realization period - beginning
Jan 1, 2006
Realization period - end
Dec 31, 2008
Project status
U - Finished project
Latest support payment
Mar 5, 2008
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP09-MZ0-NR-U/09:2
Data delivery date
Apr 27, 2011
Finance
Total approved costs
4,797 thou. CZK
Public financial support
4,539 thou. CZK
Other public sources
258 thou. CZK
Non public and foreign sources
0 thou. CZK