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NR9423

Genes involved in XME, DNA repair and cell cycle and their role in predicting risk of laryngeal cancer

Public support

  • Provider

    Ministry of Health

  • Programme

    Branch programm of research of the Ministry of Health

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví 4 (SMZ02007NR)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NR9423-3/2007

Alternative language

  • Project name in Czech

    Geny metabolizmu (XME), opravy DNA a regulace buněčného cyklu v predikci vzniku nádoru hrtanu

  • Annotation in Czech

    analýza genetických polymorfismů v genech biotransformace, DNA reparace a buněčného cyklu v lymfocytech pacientů a kontrol; stanovení molekulárně epidemiologických parametrů rakoviny hrtanu stanovení genových expresí v genech řídících opravu poškození DNA v tkání RH; mutační analýza v Check2 genu, K-ras onkogenu, Tp53 tumor supresorovém genu a MSI a LOH v mismatch reparačních genech v nádorové tkáni

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FD - Oncology and haematology

  • CEP - secondary branch

    EB - Genetics and molecular biology

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30204 - Oncology<br>30205 - Hematology

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Results of the project showed changes in gene expression of DNA repair and chromosomal damage in cancer cells. and were published in two papers in journals with impact factor.

Solution timeline

  • Realization period - beginning

    Jan 1, 2007

  • Realization period - end

    Dec 31, 2009

  • Project status

    U - Finished project

  • Latest support payment

    Dec 18, 2009

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP10-MZ0-NR-U/03:3

  • Data delivery date

    Apr 27, 2011

Finance

  • Total approved costs

    6,260 thou. CZK

  • Public financial support

    5,908 thou. CZK

  • Other public sources

    352 thou. CZK

  • Non public and foreign sources

    0 thou. CZK