New prognostic markers and epigenetic characterization of prostate cancer
Public support
Provider
Ministry of Health
Programme
Branch programm of research of the Ministry of Health
Call for proposals
VaV pro Ministerstvo zdravotnictví 4 (SMZ02007NR)
Main participants
—
Contest type
VS - Public tender
Contract ID
NR9475-3/2007
Alternative language
Project name in Czech
Nové prognostické znaky a epigenetická charakteristika nádorů prostaty
Annotation in Czech
Studium na ligandu nezávislé regulace androgenového receptoru. Objasnit úlohu korepresorů na ligandu nezávislé regulaci androgenového receptoru. Objasnit úlohu histonových deacetyláz na ligandu nezávislé regulaci androgenového receptoru. Sledovat efekt kombinace inhibitoru deacetyláz (NaB) a inhibitoru DNA metylace (5-Aza-CdR) u transkripčně neaktivního genu ZNF185.
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
EB - Genetics and molecular biology
CEP - secondary branch
FD - Oncology and haematology
CEP - another secondary branch
FE - Other fields of internal medicine
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30204 - Oncology<br>30205 - Hematology<br>30217 - Urology and nephrology<br>30218 - General and internal medicine<br>30219 - Gastroenterology and hepatology<br>30220 - Andrology
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
The method of ChIP analysis coupled with qPCR we next pursued the induced formation of AR-SMRT complex binding on PSA promoter. We detected in vitro the AR-SMRT complex formation in NaB treated cells.
Solution timeline
Realization period - beginning
Jan 1, 2007
Realization period - end
Dec 31, 2009
Project status
U - Finished project
Latest support payment
Dec 18, 2009
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP10-MZ0-NR-U/03:3
Data delivery date
Apr 27, 2011
Finance
Total approved costs
2,320 thou. CZK
Public financial support
2,189 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
131 thou. CZK