P-glycoprotein and its possible contribution to development of resistance to Imatinib in Bcr-Abl expressing cells

Provider

Ministry of Health

Programme

Branch programm of research of the Ministry of Health

Call for proposals

VaV pro Ministerstvo zdravotnictví 4 (SMZ02007NR)

Main participants

—

Contest type

VS - Public tender

Contract ID

NR9482-3/2007

Project name in Czech

P-glykoprotein a jeho možný podíl na vzniku resistence vůči imatinibu u buněk exprimujících Bcr-Abl tyrosin kinázu

Annotation in Czech

Studium podílu aktivity P-glykoproteinu na vzniku rezistence vůči imatinibu (STI571) u buněk exprimujících Bcr-Abl tyrosin kinázu pomocí přímého stanovení intracelulární koncentrace tohoto léčiva.

R&D category

NV - Nonindustrial research (Applied research excluded Industrial research)

CEP classification - main branch

FD - Oncology and haematology

CEP - secondary branch

EB - Genetics and molecular biology

CEP - another secondary branch

—

OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30204 - Oncology<br>30205 - Hematology

Provider evaluation

V - Vynikající výsledky projektu (s mezinárodním významem atd.)

Project results evaluation

Aimes of the project were fulfilled, and the results were published in two scientific journals with an impact factor..

Realization period - beginning

Jan 1, 2007

Realization period - end

Dec 31, 2009

Project status

U - Finished project

Latest support payment

Dec 18, 2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP10-MZ0-NR-U/03:3

Data delivery date

Apr 27, 2011

Total approved costs

3,184 thou. CZK

Public financial support

3,116 thou. CZK

Other public sources

45 thou. CZK

Non public and foreign sources

23 thou. CZK