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NS10109

Ischaemia - reperfusion injury and hemodynamics in porcine model of ruptured abdominal aorta aneurysm

Public support

  • Provider

    Ministry of Health

  • Programme

    Departmental Programme of Research and Development - MH II from 2008 to 2011

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví II 1 (SMZ0200801)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NS10109-4/2008

Alternative language

  • Project name in Czech

    Prasečí model ruptury aneurysmatu abdominální aorty. Vliv časování hyperoxie na parametry inflamace a ischemicko-reperfuzního traumatu

  • Annotation in Czech

    Rozvoj klinicky relevantního prasečího ischemicko-reperfuzního modelu ruptury aneurysmatu břišní aorty. Bude sledováno ovlivnění hemodynamiky, tkáňového metabolismu, oxidačního stresu a aktivace zánětu. Následně bude ukoumána možnost ovlivnění pomocí hyperoxie.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FJ - Surgery including transplantology

  • CEP - secondary branch

    ED - Physiology

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30105 - Physiology (including cytology)<br>30212 - Surgery<br>30213 - Transplantation

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    A comprehensive pig model of ruptured abdominal aortic aneurysm repair (rAAA) was validated. Hyperoxia given for the prolonged perioperative period had only minor effects on the clinical course of rAAA.

Solution timeline

  • Realization period - beginning

    Jul 1, 2008

  • Realization period - end

    Dec 31, 2011

  • Project status

    U - Finished project

  • Latest support payment

    Aug 8, 2011

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP12-MZ0-NS-U/09:3

  • Data delivery date

    Oct 31, 2013

Finance

  • Total approved costs

    6,303 thou. CZK

  • Public financial support

    5,981 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    322 thou. CZK