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NS9624

Fragment and quantitative profiling of cell free fetal nucleic acids from maternal plasma in pathological and physiological pregnancies

Public support

  • Provider

    Ministry of Health

  • Programme

    Departmental Programme of Research and Development - MH II from 2008 to 2011

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví II 1 (SMZ0200801)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NS9624-3/2008

Alternative language

  • Project name in Czech

    Fragmentační a kvantitativní profilování volných nukleových kyselin v maternální plazmě u patologických a fyziologických těhotenství.

  • Annotation in Czech

    Projekt je zaměřen především na testování korelace mezi kvantitou a velikostí volné fetální NA v maternální plazmě v průběhu těhotenství u patologií a normálních kontrol. Budou porovnávána data z analýzy STR lokusů, SNP a z gonozomálních sekvencí.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    EB - Genetics and molecular biology

  • CEP - secondary branch

    FK - Gynaecology and obstetrics

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30214 - Obstetrics and gynaecology

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    Project demostrates a greater yield of cffDNA separation on a silica gel membrane and siognificant correlatiomn between the amount of cffDNA and maternal DNA. It was able to quantify cffDNA by analysis of SNPs in DNA and RNA by STR and using QF PCR.

Solution timeline

  • Realization period - beginning

    Jul 1, 2008

  • Realization period - end

    Jun 30, 2011

  • Project status

    U - Finished project

  • Latest support payment

    Jul 16, 2010

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP12-MZ0-NS-U/09:3

  • Data delivery date

    Oct 31, 2013

Finance

  • Total approved costs

    3,225 thou. CZK

  • Public financial support

    2,954 thou. CZK

  • Other public sources

    271 thou. CZK

  • Non public and foreign sources

    0 thou. CZK