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NS9634

Determination of SNP and DNA methylation profiles in patients with myelodysplatic syndrome by microarrays.

Public support

  • Provider

    Ministry of Health

  • Programme

    Departmental Programme of Research and Development - MH II from 2008 to 2011

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví II 1 (SMZ0200801)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NS9634-4/2008

Alternative language

  • Project name in Czech

    Stanovení SNP a DNA methylačního profilu u pacientů s myelodysplastickým syndromem pomocí mikročipové technologie.

  • Annotation in Czech

    Anotace I. Předmětem předkládaného projektu je vytvoření SNP a DNA methylačního profilu pacientů s myelodysplastickým syndromem. Anotace II. K vytvoření profilů bude použita mikročipová technologie firmy Illumina, konkrétně "Cancer SNP Panel" pro detekci1421 jednonukleotidových polymorfismů nacházejících se v 408 genech a "Methylation Cancer Panel" pro detekci 1505 CpG lokusů vybraných z 807 genů.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    EB - Genetics and molecular biology

  • CEP - secondary branch

    FD - Oncology and haematology

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30204 - Oncology<br>30205 - Hematology

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    MDS is a hematologic disease at which we monitored methylation profiles and single nucleotide polymorphisms within the association study. We found an association with DNA repair genes and hypermethylation of promoters of several transcription factors.

Solution timeline

  • Realization period - beginning

    Jul 1, 2008

  • Realization period - end

    Dec 31, 2011

  • Project status

    U - Finished project

  • Latest support payment

    Aug 8, 2011

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP12-MZ0-NS-U/09:3

  • Data delivery date

    Oct 31, 2013

Finance

  • Total approved costs

    5,986 thou. CZK

  • Public financial support

    5,986 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK