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NT11230

Pharmacological blockade of cytochrome P450 pathway as a new approach in hypertension treatment

Public support

  • Provider

    Ministry of Health

  • Programme

    Ministry of Health?s Departmental Research and Development Programme III

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví III 1 (SMZ0201001)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NT11230-4/2010

Alternative language

  • Project name in Czech

    Farmakologická blokáda metabolické cesty cytochromu P450 jako nový možný přístup k léčbě hypertenze

  • Annotation in Czech

    Bude studován vliv zvýšených koncentrací epoxyeikosatrienových kyselin navozený farmakologickou blokádou jejich degradace, tj. inhibicí solubilní epoxid hydrolázy, na rozvoj ANG II-dependentní formy hypertenze.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FA - Cardiovascular diseases including cardio-surgery

  • CEP - secondary branch

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30201 - Cardiac and Cardiovascular systems

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Pharmacological blockade of soluble epoxide hydrolase increased tissue levels of epoxyeicosatrienoic acids and exhibited important antihypertensive and renoprotective actions in angiotensin II-dependent models of hypertension.

Solution timeline

  • Realization period - beginning

    Sep 1, 2010

  • Realization period - end

    Dec 31, 2013

  • Project status

    U - Finished project

  • Latest support payment

    Mar 26, 2013

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP14-MZ0-NT-U/04:2

  • Data delivery date

    Sep 2, 2014

Finance

  • Total approved costs

    5,724 thou. CZK

  • Public financial support

    5,724 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK