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ČeštinaEnglish

Primary progressive aphasia – clinical, MRI and structural correlations. A prospective multicenter study

Project goals

Primary progressive aphasias (PPA) are neurodegenerative disorders with an initial isolated language impairment progressing into dementia. Data about individual progression of PPA patients are sparse, as most large studies are retrospective. The project is designed as a prospective longitudinal multicenter cohort study. We emphasize to include 50-60 PPA patients, as comparative cohorts 20-30 patients with frontotemporal dementia, 20-30 Alzheimer’s disease patients and 20-30 patients with vascular aphasia. We already dispose of data from 50 mild cognitive impairment subjects, 50 Parkinson disease subjects and 50 healthy controls. All patients will be examined using neuropsychological tests, MRI, biomarkers of neurodegeneration; and in selected patients, neuropathological examination will be done. Expected outcomes include improvement of early diagnosis of PPA, composition of an appropriate neuropsychological battery for early assessment of PPA subtypes and their linguistic analysis and better prognostic estimates in PPA.

Keywords

magnetická rezonancemagnetic resonance imagingdemencedementianeurodegenerationAlzheimer's diseaseAlzheimerova nemocprogresivní afázieneurodegeneracefrontotemporální demenceafázieprimary progressive aphasiafrontotemporal dementiaaphasia

Public support

  • Provider

    Ministry of Health

  • Programme

    Programme to support medical applied research in 2015 to 2022

  • Call for proposals

    Zdravotnický AV 4 (SMZ0201800001)

  • Main participants

    Univerzita Karlova / 1. lékařská fakulta

  • Contest type

    VS - Public tender

  • Contract ID

    NV18-04-00346

Alternative language

  • Project name in Czech

    Primární progresivní afázie - klinické, MRI a strukturální korelace. Prospektivní multicentrická studie

  • Annotation in Czech

    Primární progresivní afázie (PPA) jsou neurodegenerativní onemocnění, která se vyznačují izolovanou alterací řeči s postupnou progresí do demence. Je jen málo údajů o individuální progresi pacientů s PPA a větší publikované studie jsou retrospektivní. Navrhovaný projekt je koncipován jako longitudinální multicentrická kohortová studie. Předpokládáme vyšetření 50-60 pacientů s PPA. Srovnávacím souborem bude 20-30 pacientů s frontotemporální demencí, 20-30 pacientů s Alzheimerovu nemocí, a 20-30 pacientů s vaskulární afázií. V současné době již disponujeme daty od 50 pacientů s mírnou kognitivní poruchou, 50 pacientů s Parkinsonovou nemocí a 50 zdravých dobrovolníků. Pacienti budou vyšetřováni neuropsychologickými testy, MRI, budou stanovovány biomarkery neurodegenerací a ve vybraných případech i neuropatologické vyšetření. Výstupem bude zlepšení časné diagnózy PPA, vytvoření baterie neuropsychologických testů pro včasnou diagnózu, lingvistická analýz subtypů PPA a zpřesnění prognostického očekávání u pacientů s PPA.

Scientific branches

  • R&D category

    AP - Applied research

  • OECD FORD - main branch

    30210 - Clinical neurology

  • OECD FORD - secondary branch

    —

  • OECD FORD - another secondary branch

    —

  • FH - Neurology, neuro-surgery, nuero-sciences

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    The aim of the study was early diagnosis of the main variants of primary progressive aphasia (PPA), nonfluent/agrammatic, semantic and logopenic variants with the aim of comparing clinical, cognitive, neuroimaging and neuropathological findings and characteristics. A total of 54 patients were examined and evaluated within the project. Recruitment of new patients has been extended as part of the forced suspension of research due to the COVID-19 pandemic. All project objectives were met and the results were published in 10 IF journals. One article (Behavioural Neurology) was dedicated exclusively to the AZV project NV 18-04-00346 and the IP of individual hospitals (Na Homolce and Thomayer's Hospital). Other outputs had multiple dedications. The duration of the project was extended by one year, and resource for personal expenses in the last year were transferred from funds of unused funds.

Solution timeline

  • Realization period - beginning

    May 1, 2018

  • Realization period - end

    Dec 31, 2022

  • Project status

    U - Finished project

  • Latest support payment

    Apr 26, 2021

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP23-MZ0-NV-U

  • Data delivery date

    Jun 22, 2023

Finance

  • Total approved costs

    14,247 thou. CZK

  • Public financial support

    13,667 thou. CZK

  • Other public sources

    580 thou. CZK

  • Non public and foreign sources

    0 thou. CZK

Basic information

Recognised costs

14 247 CZK thou.

Public support

13 667 CZK thou.

95%

Provider

Ministry of Health

OECD FORD

Clinical neurology

Solution period

01. 05. 2018 - 31. 12. 2022

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