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OC 133

Cytochrome P450 active sites

Project goals

study of compresibility and flexibility of active sites of P450 cytocromes, forms CYP2C9 and CYP3A4

Keywords

Cytochrome P450 active sitescompresibility and flexibility studyCYP2C9CYP3A4 forms

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    COST

  • Call for proposals

    COST 4 (SMSM200600OC1)

  • Main participants

    —

  • Contest type

    VS - Public tender

  • Contract ID

    1041 /2006-32

Alternative language

  • Project name in Czech

    Aktivní místa cytochromů P450

  • Annotation in Czech

    studium kompresibility a flexibility aktivního místa cytochromů P450, forem CYP2C9 a CYP3A4

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    CE - Biochemistry

  • CEP - secondary branch

    —

  • CEP - another secondary branch

    —

  • 10608 - Biochemistry and molecular biology
    10609 - Biochemical research methods

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Flexibility identified by absorption spectroscopy under pressure, by Raman spectroscopy and by molecular dynamics corresponds to binding of substrates of greater or smaller size.

Solution timeline

  • Realization period - beginning

    Mar 1, 2006

  • Realization period - end

    Nov 30, 2007

  • Project status

    U - Finished project

  • Latest support payment

    Mar 5, 2007

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP08-MSM-OC-U/01:1

  • Data delivery date

    Jun 10, 2008

Finance

  • Total approved costs

    1,180 thou. CZK

  • Public financial support

    800 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    380 thou. CZK

Basic information

Recognised costs

1 180 CZK thou.

Public support

800 CZK thou.

67%

Provider

Ministry of Education, Youth and Sports

CEP

CE - Biochemistry

Solution period

01. 03. 2006 - 30. 11. 2007